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dc.creatorCalvete Chornet, Juan Josées_ES
dc.creatorCid, Pedroes_ES
dc.creatorSanz, Libiaes_ES
dc.creatorSegura Ruiz, Álvaroes_ES
dc.creatorVillalta Arrieta, Maurenes_ES
dc.creatorHerrera Vega, Maríaes_ES
dc.creatorLeón Montero, Guillermoes_ES
dc.creatorHarrison, Robert A.es_ES
dc.creatorDurfa, Nandules_ES
dc.creatorNasidi, Abdulsalamies_ES
dc.creatorTheakston, R. David G.es_ES
dc.creatorWarrell, David A.es_ES
dc.creatorGutiérrez, José Maríaes_ES
dc.date.accessioned2016-11-23T17:48:26Zes_ES
dc.date.available2016-11-23T17:48:26Zes_ES
dc.date.issued2010es_ES
dc.identifier.citationhttp://www.ajtmh.org/content/82/6/1194.longes_ES
dc.identifier.issn0002-9637es_ES
dc.identifier.urihttp://hdl.handle.net/10669/29315es_ES
dc.description.abstractThe immunoreactivity of EchiTAb-Plus-ICP, an antivenom developed for the treatment of snakebite envenoming in sub-Saharan Africa, to venoms of seven Echis and Bitis species, was assessed by “antivenomics.” This proteomic approach is based on the ability of an antivenom to immunodeplete homologous or heterologous venom proteins. Our results show an extensive cross-reactivity of this antivenom against all Echis and Bitis venoms studied, as revealed by the complete immunodepletion of the majority of venom components, including metalloproteinases, serine proteinases, C-type lectin-like proteins, some phospholipases A2 and L-amino acid oxidase. However, some phospholipases A2, disintegrins and proteinase inhibitors were immunodepleted to only a partial extent. These results support the hypothesis that immunizing horses with a mixture of the venoms of Echis ocellatus, Bitis arietans, and Naja nigricollis generates antibodies capable of recognizing the majority of components of medically-relevant homologous and heterologous viperid venoms of the genera Bitis and Echis from sub-Saharan Africa.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A9-003]/UCR/Costa Ricaes_ES
dc.description.sponsorshipConsejo Superior de Investigaciones Científicas/[2007CR0004]/CRUSA-CSIC/Españaes_ES
dc.description.sponsorshipMinisterio de Innovación y Ciencia/[BFU2007-61563]//Españaes_ES
dc.description.sponsorshipFederal Ministry of Health///Nigeriaes_ES
dc.description.sponsorshipEchiTAb Study Group///es_ES
dc.language.isoen_USes_ES
dc.sourceThe American Journal of Tropical Medicine and Hygene; Volumen 82, Número 6. 2010es_ES
dc.subjectAfrica South of the Saharaes_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectHumanses_ES
dc.subjectImmunoprecipitationes_ES
dc.subjectSnake Biteses_ES
dc.subjectViper Venomses_ES
dc.subjectViperidaees_ES
dc.subjectSnake venomes_ES
dc.titleAntivenomic Assessment of the Immunological Reactivity of EchiTAb-Plus-ICP, an Antivenom for the Treatment of Snakebite Envenoming in Sub-Saharan Africaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.4269/ajtmh.2010.09-0733es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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