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dc.creatorRehkopf, David H.
dc.creatorDow, William H.
dc.creatorRosero Bixby, Luis
dc.creatorLin, Jue
dc.creatorEpel, Elissa S.
dc.creatorBlackburn, Elizabeth H.
dc.date.accessioned2016-12-06T21:39:20Z
dc.date.available2016-12-06T21:39:20Z
dc.date.issued2014
dc.identifier.citationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136920/es_ES
dc.identifier.issn1520-6300
dc.identifier.urihttp://hdl.handle.net/10669/29362
dc.description.abstractABSTRACT: Objectives: Peripheral blood leukocyte telomere length (LTL) is increasingly being used as a biomarker of aging, but its natural variation in human populations is not well understood. Several other biomarkers show seasonal variation, as do several determinants of LTL. We examined whether there was monthly variation in LTL in Costa Rica, a country with strong seasonal differences in precipitation and infection. Methods: We examined a longitudinal population-based cohort of 581 Costa Rican adults age 60 and above, from which blood samples were drawn between October 2006 and July 2008. LTL was assayed from these samples using the quantitative PCR method. Multivariate regression models were used to examine correlations between month of blood draw and LTL. Results: Telomere length from peripheral blood leukocytes varied by as much as 200 base pairs depending on month of blood draw, and this difference is not likely to be due to random variation. A moderate proportion of this association is statistically accounted for by month and region specific average rainfall. We found shorter telomere length associated with greater rainfall. Conclusions: There are two possible explanations of our findings. First, there could be relatively rapid month-to-month changes in LTL. This conclusion would have implications for understanding the natural population dynamics of telomere length. Second, there could be seasonal differences in constituent cell populations. This conclusion would suggest that future studies of LTL use methods to account for the potential impact of constituent cell type.es_ES
dc.description.sponsorshipWellcome Trust///Estados Unidoses_ES
dc.description.sponsorshipNational Institute on Aging///Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceAmerican Journal of Human Biology; Volumen 26, Número 3. 2014es_ES
dc.subjectAgedes_ES
dc.subjectAginges_ES
dc.subjectBiomarkerses_ES
dc.subjectCosta Ricaes_ES
dc.subjectGenetic Variationes_ES
dc.subjectHumanses_ES
dc.subjectLeukocyteses_ES
dc.subjectLongitudinal Studieses_ES
dc.subjectMiddle Agedes_ES
dc.subjectMultivariate Analysises_ES
dc.subjectRegression Analysises_ES
dc.subjectSeasonses_ES
dc.subjectTelomere Homeostasises_ES
dc.subjectTelomere Shorteninges_ES
dc.titleSeasonal Variation of Peripheral Blood Leukocyte Telomere Length in Costa Rica: A Population-Based Observational Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1002/ajhb.22529
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP)es_ES


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