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Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu

Artículo científico
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249_2007_Toxicon_Pérez_serine proteinase_B. jararacussu.pdf (390.3Kb)
Date
2007-06-01
Author
Pérez, Aida Verónica
Saravia Otten, Patricia
Rucavado Romero, Alexandra
Sant’Ana, Carolina D.
Soares, Andreimar Martins
Gutiérrez, José María
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Abstract
The local and systemic pathophysiological alterations induced by BjussuSP-I, a thrombin-like serine proteinase from the venom of the snake Bothrops jararacussu, were assessed in mice. BjussuSP-I induced a mild edema but no local myonecrosis or hemorrhage. It did not induce any microvascular alteration in the cremaster muscle. Intramuscular injection of BjussuSP-I promoted an increase in the expression of proMMP-9, but it did not induce the activation of proMMP-2 or proMMP-9 synthesized in muscle tissue injected with a myotoxic phospholipase A2 homolog. BjussuSP-I induced defibrin(ogen)ation upon intravenous and intramuscular injections, with reduction in plasma fibrinogen concentration and increments in the levels of fibrin degradation products and D-dimer. When compared with animals having normal coagulation, mice defibrin(ogen)ated by BjussuSP-I developed a slightly larger hemorrhagic lesion in the skin when injected with metalloproteinase BaP1. Intravenous injection of sublethal doses of BjussuSP-I promoted a series of behavioral and motor changes similar to those previously described for ‘gyroxin’, i.e. opisthotonus and a circular body movement along the longitudinal axis.
URI
http://hdl.handle.net/10669/29382
External link to the item
10.1016/j.toxicon.2006.12.011
http://www.sciencedirect.com/science/article/pii/S0041010106004764
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  • Microbiología [880]



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  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
Universidad de Costa Rica