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Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu
dc.creator | Pérez, Aida Verónica | |
dc.creator | Saravia Otten, Patricia | |
dc.creator | Rucavado Romero, Alexandra | |
dc.creator | Sant’Ana, Carolina D. | |
dc.creator | Soares, Andreimar Martins | |
dc.creator | Gutiérrez, José María | |
dc.date.accessioned | 2016-12-09T17:21:55Z | |
dc.date.available | 2016-12-09T17:21:55Z | |
dc.date.issued | 2007-06-01 | |
dc.identifier.citation | http://www.sciencedirect.com/science/article/pii/S0041010106004764 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.uri | https://hdl.handle.net/10669/29382 | |
dc.description.abstract | The local and systemic pathophysiological alterations induced by BjussuSP-I, a thrombin-like serine proteinase from the venom of the snake Bothrops jararacussu, were assessed in mice. BjussuSP-I induced a mild edema but no local myonecrosis or hemorrhage. It did not induce any microvascular alteration in the cremaster muscle. Intramuscular injection of BjussuSP-I promoted an increase in the expression of proMMP-9, but it did not induce the activation of proMMP-2 or proMMP-9 synthesized in muscle tissue injected with a myotoxic phospholipase A2 homolog. BjussuSP-I induced defibrin(ogen)ation upon intravenous and intramuscular injections, with reduction in plasma fibrinogen concentration and increments in the levels of fibrin degradation products and D-dimer. When compared with animals having normal coagulation, mice defibrin(ogen)ated by BjussuSP-I developed a slightly larger hemorrhagic lesion in the skin when injected with metalloproteinase BaP1. Intravenous injection of sublethal doses of BjussuSP-I promoted a series of behavioral and motor changes similar to those previously described for ‘gyroxin’, i.e. opisthotonus and a circular body movement along the longitudinal axis. | es_ES |
dc.description.sponsorship | /[grant 2-N-2005]/NeTropica/Estados Unidos | es_ES |
dc.description.sponsorship | Vicerrectoría de Investigación/[741-A6-505]/UCR/Costa Rica | es_ES |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo//FAPESP/Brasil | es_ES |
dc.description.sponsorship | Conselho Nacional de De-senvolvimento Cientı́fico e Tecnológico//CNPq/Brasil | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Toxicon; Volumen 49, Número 7. 2007 | es_ES |
dc.subject | Thrombin-like | es_ES |
dc.subject | Bothrops Jararacussu | es_ES |
dc.subject | MMPs | es_ES |
dc.subject | Serine Proteinase | es_ES |
dc.subject | Defibrin(ogen)ation | es_ES |
dc.title | Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1016/j.toxicon.2006.12.011 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
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Microbiología [1171]