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dc.creatorLeón Montero, Guillermo
dc.creatorRojas Céspedes, Gustavo
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.date.accessioned2016-12-15T16:46:55Z
dc.date.available2016-12-15T16:46:55Z
dc.date.issued1997-11
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010197000342es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29408
dc.description.abstractThe ability of whole immunoglobulin G (IgG) and F(ab')2 polyvalent (Crotalinae) antivenoms to neutralize the hemorrhagic, edema-forming and myotoxic activities of Bothrops asper venom was studied. Both antivenoms were adjusted to the same neutralizing potency against lethal and hemorrhagic activities in experiments where venom and antivenoms were incubated before injection. Thus, in these experimental conditions, differences in the neutralizing ability in experiments involving independent injection of venom and antivenoms would depend mainly on the different pharmacokinetic profiles of whole IgG and F(ab')2 antivenoms. Experiments involving local injection of venom followed by intravenous administration of antivenom at either 0, 15 or 30 min after envenomation did not reveal any significant difference between whole IgG and F(ab')2 products concerning neutralization of hemorrhage, edema and myonecrosis induced by B. asper venom. The three effects were neutralized by antivenoms only to a partial extent and neutralization decreased as the time-lapse between envenomation and antivenom administration increased. Moreover, with the exception of one time-interval, no significant differences in the neutralization of hemorrhage were observed when antivenom was administered by the intramuscular or intraperitoneal route. The results do not support the assumption that F(ab')2 antivenom is more effective than whole IgG antivenom in the neutralization of local hemorrhage, edema and myonecrosis induced by B. asper venom in mice.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-87-057]/UCR/Costa Ricaes_ES
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnología//CONICIT/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 35, Número 11, 1997es_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectBothropses_ES
dc.subjectCrotalid Venomses_ES
dc.subjectEdemaes_ES
dc.subjectHemorrhagees_ES
dc.subjectImmunoglobulin Fab Fragmentses_ES
dc.subjectImmunoglobulin Ges_ES
dc.subjectMicees_ES
dc.subjectMuscle, Skeletales_ES
dc.subjectNecrosises_ES
dc.subjectNeutralization Testses_ES
dc.subjectSnake venomes_ES
dc.titleImmunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/S0041-0101(97)00034-2
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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