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dc.creatorPetras, Daniel
dc.creatorSanz, Libia
dc.creatorSegura Ruiz, Álvaro
dc.creatorHerrera Vega, María
dc.creatorVillalta Arrieta, Mauren
dc.creatorSolano, Daniela
dc.creatorVargas Arroyo, Mariángela
dc.creatorLeón Montero, Guillermo
dc.creatorWarrell, David A.
dc.creatorTheakston, R. David G.
dc.creatorHarrison, Robert A.
dc.creatorDurfa, Nandul
dc.creatorNasidi, Abdulsalami
dc.creatorGutiérrez, José María
dc.creatorCalvete Chornet, Juan José
dc.date.accessioned2017-01-18T20:08:51Z
dc.date.available2017-01-18T20:08:51Z
dc.date.issued2011
dc.identifier.citationhttp://pubs.acs.org/doi/abs/10.1021/pr101040fes_ES
dc.identifier.issn1535-3907
dc.identifier.urihttp://hdl.handle.net/10669/29437
dc.descriptionEmbargo por política editorial 2081-01-01es_ES
dc.description.abstractVenomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica, and N. pallida revealed similar compositional trends. The high content of cytotoxins and PLA2s may account for the extensive tissue necrosis characteristic of the envenomings by these species. The high abundance of a type I α-neurotoxin in N. nubiae may be responsible for the high lethal toxicity of this venom (in rodents). The ability of EchiTAb-Plus-ICP antivenom to immunodeplete and neutralize the venoms of African spitting cobras was assessed by antivenomics and neutralization tests. It partially immunodepleted 3FTx and PLA2s and completely immunodepleted SVMPs and CRISPs in all venoms. The antivenom neutralized the dermonecrotic and PLA2 activities of all African Naja venoms, whereas lethality was eliminated in the venoms of N. nigricollis, N. mossambica, and N. pallida but not in those of N. nubiae and N. katiensis. The lack of neutralization of lethality of N. nubiae venom may be of medical relevance only in relatively populous areas of the Saharan region. The impaired activity of EchiTAb-Plus-ICP against N. katiensis may not represent a major concern. This species is sympatric with N. nigricollis in many regions of Africa, although very few bites have been attributed to it.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A9-003]/UCR/Costa Ricaes_ES
dc.description.sponsorship/2009CR0021/CRUSA-CSIC/Españaes_ES
dc.description.sponsorshipMinisterio de Innovación y Ciencia/[BFU2007-61563]//Españaes_ES
dc.description.sponsorshipMinisterio de Innovación y Ciencia/[BFU2010-17373]//Españaes_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Proteome Research; Volumen 10, Número 3. 2011es_ES
dc.subjectAfrican spitting cobraes_ES
dc.subjectAntivenomicses_ES
dc.subjectEchiTAb-Plus-ICP antivenomes_ES
dc.subjectNaja katiensises_ES
dc.subjectNaja mossambicaes_ES
dc.subjectNaja nigricollises_ES
dc.subjectNaja nubiaees_ES
dc.subjectNaja pallidaes_ES
dc.subjectVenom neutralization assayses_ES
dc.subjectSnake venomes_ES
dc.titleSnake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approacheses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1021/pr101040f
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-A9-003


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