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dc.creatorLeón Montero, Guillermo
dc.creatorValverde, Juan Manuel
dc.creatorRojas Céspedes, Gustavo
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.date.accessioned2017-01-24T17:35:13Z
dc.date.available2017-01-24T17:35:13Z
dc.date.issued2000-02
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S004101019900152Xes_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29460
dc.description.abstractThe ability of sheep antivenoms, consisting of whole IgG molecules or Fab fragments, to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper venom was comparatively studied in mice. The two antivenoms were produced from the same batch of hyperimmune plasma and were adjusted to the same neutralizing potency against these effects in assays where venom and antivenoms were incubated prior to injection. Thus, if differences are observed in experiments involving independent injection of venom and antivenoms, they would depend on the pharmacokinetic profiles of the products. Despite the observation that both antivenoms neutralized the three effects if preincubated with venom, neutralization was only partial when antivenoms were administered i.v. at various time intervals after envenomation. No significant differences were observed between IgG and Fab antivenoms concerning neutralization of hemorrhagic and edema-forming activities, whereas IgG antivenom was slightly more effective in neutralizing myotoxic activity in experiments involving independent injection of venom and antivenom. These results do not support the hypothesis that Fab fragments are more effective than whole IgG molecules in the neutralization of locally-acting toxins from B. asper venom.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-89-057]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volúmen 38, Número 2. 2000es_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectCreatine Kinasees_ES
dc.subjectCrotalid Venomses_ES
dc.subjectEdemaes_ES
dc.subjectHemorrhagees_ES
dc.subjectImmunoglobulin Fab Fragmentses_ES
dc.subjectImmunoglobulin Ges_ES
dc.subjectMicees_ES
dc.subjectMuscleses_ES
dc.subjectNecrosises_ES
dc.subjectSheepes_ES
dc.subjectSnake venomes_ES
dc.titleComparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/S0041-0101(99)00152-X
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-89-057


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