Mostrar el registro sencillo del ítem
Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms
dc.creator | Dos Santos, María Cristina | |
dc.creator | Arroyo Portilla, Cynthia | |
dc.creator | Solano Rojas, Sergio | |
dc.creator | Herrera Vega, María | |
dc.creator | Villalta Arrieta, Mauren | |
dc.creator | Segura Ruiz, Álvaro | |
dc.creator | Estrada Umaña, Ricardo | |
dc.creator | Gutiérrez, José María | |
dc.creator | León Montero, Guillermo | |
dc.date.accessioned | 2017-02-22T20:39:43Z | |
dc.date.available | 2017-02-22T20:39:43Z | |
dc.date.issued | 2011-02 | |
dc.identifier.citation | http://www.sciencedirect.com/science/article/pii/S0041010110004125 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.uri | https://hdl.handle.net/10669/29551 | |
dc.description | Embargo por política editorial 2081-01-02 | es_ES |
dc.description.abstract | Antivenoms are preparations of immunoglobulins purified from the plasma of animals immunized with snake venoms. Depending on the number of venoms used during the immunization, antivenoms can be monospecific (if venom from a single species is used) or polyspecific (if venoms from several species are used). In turn, polyspecific antivenoms can be prepared by purifying antibodies from the plasma of animals immunized with a mixture of venoms, or by mixing antibodies purified from the plasma of animals immunized separately with single venom. The suitability of these strategies to produce polyspecific antibothropic-crotalic antivenoms was assessed using as models the venoms of Bothrops asper, Crotalus simus and Crotalus durissus ruruima. It was demonstrated that, when used as co-immunogen, C. simus and C. durissus ruruima venoms exert a deleterious effect on the antibody response towards different components of B. asper venom and in the neutralization of hemorrhagic and coagulant effect of this venom when compared with a monospecific B. asper antivenom. Polyspecific antivenoms produced by purifying immunoglobulins from the plasma of animals immunized with venom mixtures showed higher antibody titers and neutralizing capacity than those produced by mixing antibodies purified from the plasma of animals immunized separately with single venom. Thus, despite the deleterious effect of Crotalus sp venoms on the immune response against B. asper venom, the use of venom mixtures is more effective than the immunization with separate venoms for the preparation of polyspecific bothropic–crotalic antivenoms. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica/[741-A9-003]/UCR/Costa Rica | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Toxicon; Volumen 57, Número 2. 2011 | es_ES |
dc.subject | Snake venom | es_ES |
dc.subject | Bothrops asper | es_ES |
dc.subject | Crotalus simus | es_ES |
dc.subject | Crotalus durissus ruruima | es_ES |
dc.subject | Immunization | es_ES |
dc.subject | Immunomodulation | es_ES |
dc.subject | Snake antivenom | es_ES |
dc.title | Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1016/j.toxicon.2010.11.016 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
dc.identifier.codproyecto | 741-A9-003 | |
dc.identifier.pmid | 21130107 |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Microbiología [1171]