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dc.creatorGutiérrez, José María
dc.creatorEscalante Muñoz, Teresa
dc.creatorRucavado Romero, Alexandra
dc.creatorHerrera Arias, Cristina
dc.date.accessioned2017-06-30T17:51:52Z
dc.date.available2017-06-30T17:51:52Z
dc.date.issued2016-03-26
dc.identifier.citationhttp://www.mdpi.com/2072-6651/8/4/93es_ES
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/10669/30166
dc.description.abstractThe historical development of discoveries and conceptual frames for understanding the hemorrhagic activity induced by viperid snake venoms and by hemorrhagic metalloproteinases (SVMPs) present in these venoms is reviewed. Histological and ultrastructural tools allowed the identification of the capillary network as the main site of action of SVMPs. After years of debate, biochemical developments demonstrated that all hemorrhagic toxins in viperid venoms are zinc-dependent metalloproteinases. Hemorrhagic SVMPs act by initially hydrolyzing key substrates at the basement membrane (BM) of capillaries. This degradation results in the weakening of the mechanical stability of the capillary wall, which becomes distended owing of the action of the hemodynamic biophysical forces operating in the circulation. As a consequence, the capillary wall is disrupted and extravasation occurs. SVMPs do not induce rapid toxicity to endothelial cells, and the pathological effects described in these cells in vivo result from the mechanical action of these hemodynamic forces. Experimental evidence suggests that degradation of type IV collagen, and perhaps also perlecan, is the key event in the onset of microvessel damage. It is necessary to study this phenomenon from a holistic, systemic perspective in which the action of other venom components is also taken into consideration.es_ES
dc.language.isoen_USes_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Costa Rica*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cr/*
dc.sourceToxins, Volumen 8, Número 4. 2016es_ES
dc.subjectSnake venomes_ES
dc.subjectViperidses_ES
dc.subjectMetalloproteinaseses_ES
dc.subjectHemorrhagees_ES
dc.subjectCapillary vesselses_ES
dc.subjectBasement Membranees_ES
dc.subjectType IV collagenes_ES
dc.titleHemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understandinges_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.3390/toxins8040093
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid27023608
dc.identifier.pmidPMC4848620


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Atribución-NoComercial-CompartirIgual 3.0 Costa Rica
Except where otherwise noted, this item's license is described as Atribución-NoComercial-CompartirIgual 3.0 Costa Rica