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dc.creatorPagani, Lucia
dc.creatorSt. Clair, Patricia A.
dc.creatorTeshiba, Terri M.
dc.creatorService, Susan K.
dc.creatorFears, Scott C.
dc.creatorAraya, Carmen
dc.creatorAraya, Xinia
dc.creatorBejarano Orozco, Julio
dc.creatorRamírez Pacheco, Margarita
dc.creatorCastrillón, Gabriel
dc.creatorGomez Makhinson, Juliana
dc.creatorLópez, María Cecilia
dc.creatorMontoya Montoya, Gabriel Jaime
dc.creatorMontoya Guerra, Claudia Patricia
dc.creatorAldana, Ileana
dc.creatorNavarro, Linda
dc.creatorFreimer, Daniel G.
dc.creatorSafaie, Brian
dc.creatorKeung, Lap-Woon
dc.creatorGreenspan, Kiefer
dc.creatorChou, Katty
dc.creatorEscobar, Javier I.
dc.creatorOspina Duque, Jorge
dc.creatorKremeyer, Barbara
dc.creatorRuiz Linares, Andrés
dc.creatorCantor, Rita M.
dc.creatorLópez Jaramillo, Carlos
dc.creatorMacaya Trejos, Gabriel
dc.creatorMolina, Julio
dc.creatorReus, Victor I.
dc.creatorSabatti, Chiara
dc.creatorBearden, Carrie E.
dc.creatorTakahashi, Joseph S.
dc.creatorFreimer, Nelson B.
dc.date.accessioned2017-08-04T21:00:40Z
dc.date.available2017-08-04T21:00:40Z
dc.date.issued2016-02-09
dc.identifier.citationhttp://www.pnas.org/content/113/6.toc
dc.identifier.issn1091-6490
dc.identifier.otherPMC4760829
dc.identifier.urihttps://hdl.handle.net/10669/72937
dc.description.abstractAbnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained from members of 26 Costa Rican and Colombian pedigrees [136 euthymic (i.e., interepisode) BP-I individuals and 422 non-BP-I relatives], we delineated 73 phenotypes, of which 49 demonstrated significant heritability and 13 showed significant trait-like association with BP-I. All BP-I-associated traits related to activity level, with BP-I individuals consistently demonstrating lower activity levels than their non-BP-I relatives. We analyzed all 49 heritable phenotypes using genetic linkage analysis, with special emphasis on phenotypes judged to have the strongest impact on the biology underlying BP. We identified a locus for interdaily stability of activity, at a threshold exceeding genome-wide significance, on chromosome 12pter, a region that also showed pleiotropic linkage to two additional activity phenotypes.es_ES
dc.description.sponsorshipNational Institute of Health/[R01MH075007]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Institute of Health/[R01MH095454]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Institute of Health/[P30NS062691]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Institute of Health/[T32MH073526]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Institute of Health/[K23MH074644-01]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Institute of Health/[K08MH086786]/NIH/Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceProceedings of the National Academy of Sciences; Volumen 113, Número 6. 2016.es_ES
dc.subjectBipolar Disorderes_ES
dc.subjectEndophenotypeses_ES
dc.subjectCircadian Rhythmses_ES
dc.subjectActigraphyes_ES
dc.subjectBehaviores_ES
dc.titleGenetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorderes_ES
dc.typeartículo original
dc.identifier.doi10.1073/pnas.1513525113
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es_ES
dc.identifier.pmid26712028


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