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dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.date.accessioned2017-08-08T20:52:57Z
dc.date.available2017-08-08T20:52:57Z
dc.date.issued1989
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/0041010189900391es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/72948
dc.description.abstractA new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CMSephadex C-25. The toxin is a dimeric, basic protein with a monomer mol.wt of 13,341, according to the amino acid composition, and 16,000 on the basis of SDS-polyacrylamide gel electrophoretic mobility . It has a high number of aspartate and lysine residues, as well as of hydrophobic amino acids. Upon i.m. injection into mice, the toxin induces myonecrosis and increase in serum creatine kinase levels . In addition, myotoxin II induces edema in the mouse foot pad. Immunochemical tests, mol.wt, and amino acid composition indicate a high degree ofhomology between myotoxin II and a previously characterized myotoxin from this venom, myotoxin I. However, in contrast to myotoxin I, myotoxin II lacks phospholipase A2 and anticoagulant activities in vitro.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-88-009]/UCR/Costa Ricaes_ES
dc.description.sponsorshipInternational Foundation for Science/[F/1388-1]/IFS/Sueciaes_ES
dc.description.sponsorshipEl Consejo Nacional para Investigaciones Científicas y Tecnológicas//CONICIT/COsta Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon 27, 725-733 (1989)es_ES
dc.subjectmyotoxines_ES
dc.subjectBothropses_ES
dc.subjectSnake venomes_ES
dc.titleA new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(89)90039-1
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid2781572


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