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A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo)
dc.creator | Lomonte, Bruno | |
dc.creator | Gutiérrez, José María | |
dc.date.accessioned | 2017-08-08T20:52:57Z | |
dc.date.available | 2017-08-08T20:52:57Z | |
dc.date.issued | 1989 | |
dc.identifier.citation | http://www.sciencedirect.com/science/article/pii/0041010189900391 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.uri | https://hdl.handle.net/10669/72948 | |
dc.description.abstract | A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CMSephadex C-25. The toxin is a dimeric, basic protein with a monomer mol.wt of 13,341, according to the amino acid composition, and 16,000 on the basis of SDS-polyacrylamide gel electrophoretic mobility . It has a high number of aspartate and lysine residues, as well as of hydrophobic amino acids. Upon i.m. injection into mice, the toxin induces myonecrosis and increase in serum creatine kinase levels . In addition, myotoxin II induces edema in the mouse foot pad. Immunochemical tests, mol.wt, and amino acid composition indicate a high degree ofhomology between myotoxin II and a previously characterized myotoxin from this venom, myotoxin I. However, in contrast to myotoxin I, myotoxin II lacks phospholipase A2 and anticoagulant activities in vitro. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica/[741-88-009]/UCR/Costa Rica | es_ES |
dc.description.sponsorship | International Foundation for Science/[F/1388-1]/IFS/Suecia | es_ES |
dc.description.sponsorship | El Consejo Nacional para Investigaciones Científicas y Tecnológicas//CONICIT/COsta Rica | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Toxicon 27, 725-733 (1989) | es_ES |
dc.subject | myotoxin | es_ES |
dc.subject | Bothrops | es_ES |
dc.subject | Snake venom | es_ES |
dc.title | A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo) | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1016/0041-0101(89)90039-1 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
dc.identifier.pmid | 2781572 |
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Microbiología [1170]