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dc.creatorLomonte, Bruno
dc.creatorTarkowski, Andrej
dc.creatorHanson, Lars Ake
dc.date.accessioned2017-08-28T14:18:17Z
dc.date.available2017-08-28T14:18:17Z
dc.date.issued1993
dc.identifier.citationhttps://link.springer.com/article/10.1007/BF00916097es_ES
dc.identifier.issn0360-3997
dc.identifier.urihttp://hdl.handle.net/10669/73084
dc.description.abstractAs part of tle characterization of the host reactivity to the venom of Bothrops asper, we investigated the inflammatory responses in the mouse footpad model. The subcutaneously iniected venom induced a rapid increase of serum IL-6 concentration, which peaked between 3 and 6 h and returned to normal values at 12 h. In contrast, serum TNF-c~, and IL-lc~ were not detectable at any time point studied. A myotoxic phospholipase Az isoform purified from this venom, myotoxin II, was also able to induce a systemic IL-6 release when injected into the footpad. Both venom and myotoxin induced local edema and a leukocyte infiltrate accumulating in the muscle and subdermal tissue within 6 h. The infiltrate consisted predominantly of neutrophils at 6 and 24 h, but at later times, mononuclear cells also appeared. The edema, leukocyte infiltration, and IL-6 responses did not depend on the hemorrhagic activity of venom, since all three effects were seen after injection of (1) preneutralized venom, devoid of hemorrhagic activity, and (2) purified myotoxin II. Circulating platelet numbers were significantly decreased 30 min after venom injection and returned to normal after 12 h. The venom also induced a rapid inversion in the ratio of neutrophils to lymphocytes in peripheral blood, which did not normalize until 12 h later. The presenl observations suggest that venom, besides its cytotoxic properties, induces early hematologic and immunologic alterations. These findings may be of relevance in future treatment modalities.es_ES
dc.description.sponsorshipCosta Rican National Scientific and Technological Research Council//CONICIT/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceInflammation; Volumen 17, Número 2. 1993es_ES
dc.subjectBothropses_ES
dc.subjectInflammationes_ES
dc.subjectSnake venomes_ES
dc.titleHost response to Bothrops asper snake venom: analysis of edema formation, inflammatory cells, and cytokine release in a mouse modeles_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1007/BF00916097
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid8491517


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