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dc.creatorBorkow, Gadi
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.creatorOvadia, Michael
dc.date.accessioned2017-09-12T17:31:17Z
dc.date.available2017-09-12T17:31:17Z
dc.date.issued1994
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/0041010194903301es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/73140
dc.description.abstractThe effect of various crotalid and viperid venoms at 10, 50 and 100 μg/ml was examined on bovine and murine endothelial cells in vitro. The venoms caused the cells to lose their processes, leading to the appearance of spaces which were gradually enlarged between clusters of cells. The cells became round and finally detached from the substrate. This effect was more pronounced on bovine normal cells than on murine transformed cells. Most of the venoms did not affect the viability of the cells even after 24 hr of incubation, as determined by the trypan blue dye exclusion procedure. Moreover, after the cells were washed from the venoms and transferred into fresh medium, they regained their original morphology after spreading on the substrate and they then proliferated normally. This reversible effect shows that most of the crotalid and viperid venoms examined were not directly cytotoxic to the endothelial cells at the concentrations tested.es_ES
dc.description.sponsorship/[DHR-5544-6-00-1064-00]/AID/es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon 32(12), 1689-1695. 1994es_ES
dc.subjectcytotoxicityes_ES
dc.subjectSnake venomes_ES
dc.titleEffect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitroes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/0041-0101(94)90330-1
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid7725339


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