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dc.creatorMadrigal Redondo, German
dc.creatorCarazo Berrocal, Gustavo
dc.creatorVargas Zúñiga, Rolando
dc.creatorRamírez Arguedas, Nils Antonio
dc.date.accessioned2019-03-22T20:12:48Z
dc.date.available2019-03-22T20:12:48Z
dc.date.issued2015
dc.identifier.citationhttp://saspublisher.com/wp-content/uploads/2015/02/SAJP-42102-107.pdfes_ES
dc.identifier.issn2320-4206
dc.identifier.issn2347-9531
dc.identifier.urihttp://hdl.handle.net/10669/76752
dc.description.abstractDetermining the spatial configuration of the structures of compounds used in the production of medicines is extremely important due to the different characteristics of each of them in its solid state and therefore its different qualities of each for use as pharmaceutical raw material. This study aimed to identify the phase of the solid state of Atorvastatin hemi-dihydrate, a lipid-lowering medication HMG-CoA reductase widely use in the present and their characterization by four different instrumental analytical techniques: X-ray diffractometry, differential scanning calorimetry, thermogravimetry and infrared spectroscopy, comparing the obtained analytical results with those found in the literature. Using data obtained from these four techniques are able to show that the study sample exists predominantly in the 27 form of amorphic hemi-dihydrate calcic atorvastatin.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.rightsAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceScholars Academic Journal of Pharmacy (SAJP) vol.4(2),pp.102-107es_ES
dc.subjectAtorvastatines_ES
dc.subjectDrugses_ES
dc.subjectPharmaceuthicalses_ES
dc.subjectPolimorphismes_ES
dc.subjectSolid statees_ES
dc.titleIdentification of solid phase state of hemi-dihydrate atorvastatin in pharmaceutical raw materialses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución-NoComercial-CompartirIgual 4.0 Internacional