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dc.creatorFlores Díaz, Marietta
dc.creatorMonturiol Gross, Laura
dc.creatorAlape Girón, Alberto
dc.date.accessioned2019-04-08T17:05:46Z
dc.date.available2019-04-08T17:05:46Z
dc.date.issued2015-06-05
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/B9780128001882000227?via%3Dihub#!es_ES
dc.identifier.isbn978-0-12-800188-2
dc.identifier.urihttp://hdl.handle.net/10669/76880
dc.description.abstractThis chapter presents an overview of the classification, structure, and main physiopathological activities of bacterial sphingomyelinases and phospholipases, providing examples of their roles as virulence factors in several human and animal diseases. Bacterial sphingomyelinases (SMases) and phospholipases (PLases) constitute a heterogeneous group of surface-associated or secreted esterases produced by a variety of intracellular and extracellular pathogens. These enzymes might favor in different ways tissue colonization establishment and progression of the infection, or evasion of the immune response. In several cases, mutant bacterial strains lacking a sphingomyelinase or a phospholipase encoding gene have impaired virulence in experimental animals, demonstrating the role of these enzymes in pathogenicity. However, PLases contribute also to other aspects of bacterial lifestyle, including survival in different environments, and competition with other microorganisms; thus, the multifunctional nature of these enzymes reflects the remarkable adaptability of some bacteria.es_ES
dc.language.isoen_USes_ES
dc.sourceIn: The Comprehensive Sourcebook of Bacterial Protein Toxins. Joseph Alouf, Daniel Ladant and Michel R. Popoff (eds.). United States: Academic Press. pp. 627-676.es_ES
dc.subjectSphingomyelinaseses_ES
dc.subjectPhospholipaseses_ES
dc.subjectCytotoxicityes_ES
dc.subjectMembrane damagees_ES
dc.subjectCeramidees_ES
dc.subjectPathogenicityes_ES
dc.subjectVirulencees_ES
dc.subject616.92 Enfermedades bacterianas y viraleses_ES
dc.titleMembrane-damaging and cytotoxic sphingomyelinases and phospholipaseses_ES
dc.typeinfo:eu-repo/semantics/bookPartes_ES
dc.identifier.doi10.1016/B978-0-12-800188-2.00022-7
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Docencia::Salud::Facultad de Microbiologíaes_ES
dc.description.procedenceUCR::Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES


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