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dc.creatorLeón Montero, Guillermo
dc.creatorSegura Ruiz, Álvaro
dc.creatorGómez Argüello, Aarón
dc.creatorHernández Bolaños, Andrés
dc.creatorNavarro Arias, Diego
dc.creatorVillalta Arrieta, Mauren
dc.creatorVargas Arroyo, Mariángela
dc.creatorHerrera Vega, María
dc.creatorGutiérrez, José María
dc.date.accessioned2019-05-22T20:18:45Z
dc.date.available2019-05-22T20:18:45Z
dc.date.issued2014
dc.identifier.citationhttps://link.springer.com/referenceworkentry/10.1007%2F978-94-007-6649-5_24-3es_ES
dc.identifier.isbn978-94-007-6649-5
dc.identifier.urihttp://hdl.handle.net/10669/77323
dc.description.abstractThe production of snake antivenoms involves stages such as production of venom, immunization of animals to generate hyperimmune plasma, immunoglobulin purification, viral inactivation (or removal), and stabilization of the formulation. In order to manufacture products of satisfactory effectiveness and safety, antivenom design must be validated by preclinical and clinical studies. Moreover, during the industrial production, the quality of the products and of the entire manufacturing process (including management of clean rooms, production of water for injection, and sterilization or sanitization of the equipment) must be strictly evaluated. This chapter presents a practical description of the stages involved in the design, production, and quality control of snake antivenoms.es_ES
dc.language.isoen_USes_ES
dc.sourceLeón G. et al. (2014) Industrial Production and Quality Control of Snake Antivenoms. In: Gopalakrishnakone P., Calvete J. (eds) Toxinology. Springer, Dordrechtes_ES
dc.subjectWest Nile Viruses_ES
dc.subjectCaprylic Acides_ES
dc.subjectViral Inactivationes_ES
dc.subjectSnake Specieses_ES
dc.subjectSnake venomes_ES
dc.subject615.946 Venenos animales
dc.titleIndustrial Production and Quality Control of Snake Antivenomses_ES
dc.typeinfo:eu-repo/semantics/bookPartes_ES
dc.identifier.doi10.1007/978-94-007-6649-5_24-3
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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