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Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments
dc.creator | Mike, Laura A. | |
dc.creator | Tripathi, Ashootosh | |
dc.creator | Blankenship, Connor M. | |
dc.creator | Saluk, Alyssa | |
dc.creator | Schultz, Pamela J. | |
dc.creator | Tamayo Castillo, Giselle | |
dc.creator | Sherman, David H. | |
dc.creator | Mobley, Harry L. T. | |
dc.date.accessioned | 2020-02-20T15:36:22Z | |
dc.date.available | 2020-02-20T15:36:22Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | https://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc07732g#!divAbstract | |
dc.identifier.issn | 1364-548X | |
dc.identifier.uri | https://hdl.handle.net/10669/80612 | |
dc.description.abstract | High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections. | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Chemical Communications, vol.53(95), pp.12778-12781 | es_ES |
dc.subject | Nicoyamycin A | es_ES |
dc.subject | Escherichia coli | es_ES |
dc.subject | Inhibitor | es_ES |
dc.subject | Antibiotics | es_ES |
dc.subject | Bacterial infections | es_ES |
dc.title | Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1039/c7cc07732g | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química | es_ES |
dc.identifier.pmid | 29139494 | |
dc.identifier.pmid | PMC5706644 |
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Biología [1635]