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dc.creatorRojas Carvajal, Mijail
dc.creatorSequeira Cordero, Andrey
dc.creatorBrenes Sáenz, Juan Carlos
dc.date.accessioned2020-06-11T19:33:07Z
dc.date.available2020-06-11T19:33:07Z
dc.date.issued2020-05
dc.identifier.citationhttps://www.frontiersin.org/articles/10.3389/fphar.2020.00674/full#h4es_ES
dc.identifier.issn1663-9812
dc.identifier.urihttp://hdl.handle.net/10669/81151
dc.description.abstractTo study how motivational factors modulate experience-dependent neurobehavioral plasticity, we modify a protocol of environmental enrichment (EE) in rats. We assumed that the benefits derived from EE might vary according to the level of incentive salience attributed to it. To enhance the rewarding properties of EE, access to the EE cage varied randomly from 2 to 48 h for 30 days (REE). The REE group was enriched only 50% of the time and was compared to standard housing and continuous EE (CEE) groups. As behavioral readout, we analyzed the spontaneous activity and the ultrasonic vocalizations (USVs) within the EE cage weekly, and in the open field test at the end of the experiment. In the cage, REE increased the utilization of materials, physical activity, and the rate of appetitive USVs. In the OF, the CEE-induced enhancements in novelty habituation and social signaling were equaled by the REE. At the neural level, we measured the expression of genes related to neural plasticity and epigenetic regulations in different brain regions. In the dorsal striatum and hippocampus, REE upregulated the expression of the brain-derived neurotrophic factor, its tropomyosin kinase B receptor, and the DNA methyltransferase 3A. Altogether, our results suggest that the higher activity within the cage and the augmented incentive motivation provoked by the REE boosted its neurobehavioral effects equaling or surpassing those observed in the CEE condition. As constant exposures to treatments or stimulating environments are virtually impossible for humans, restricted EE protocols would have greater translational value than traditional ones.es_ES
dc.language.isoen_USes_ES
dc.sourceFrontiers in Pharmacology, 11, 2020es_ES
dc.subjectEnvironmental enrichmentes_ES
dc.subjectNeural plasticityes_ES
dc.subjectMotivationes_ES
dc.subjectUltrasonic vocalizationses_ES
dc.subjectGroominges_ES
dc.subjectLearninges_ES
dc.subjectEmotiones_ES
dc.subjectRewardes_ES
dc.titleNeurobehavioral Effects of Restricted and Unpredictable Environmental Enrichment in Ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.3389/fphar.2020.00674
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP)es_ES
dc.identifier.codproyecto837-B7-603
dc.identifier.codproyecto723-B7-610
dc.identifier.codproyecto742-B4-240


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