Adjudicating Neurocognitive Endophenotypes for Schizophrenia
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Date
2007-03-05Author
Burk, Gary
Estrada, Jose
Peralta, Juan Manuel
Meyenberg, Naxhielli
Barrett, Jennifer
Nicolini Sánchez, José Humberto
Escamilla, Michael
Glahn, David C.
Almasy, Laura
Blangero, John
Pereira Castro, Mariana
Raventós Vorst, Henriette
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Show full item recordAbstract
Although genetic influences on schizophrenia
are well established, localization of the genes
responsible for this illness has proven extremely
difficult. Given evidence that genes predisposing
to schizophrenia may be transmitted without
expression of the clinical phenotype, efforts have
focused on developing endophenotypes. While
several neuropsychological measures have been
proposed to be endophenotypes, few studies have
systematically assessed batteries of neurocognitive
tests to determine which tests are most
sensitive to liability for the illness. Two hundred
sixty-nine Latino individualswere administered a
standard neuropsychological battery.Neurocognitive measures
found to be heritable were entered into
analyses designed to determine which tests covary
with the degree of genetic relationship to
affected individuals
External link to the item
10.1002/ajmg.b.30446
artículo (arbitrado) -- Universidad de Costa Rica. Centro de Investigación de Biología Celular y Molecular, 2007. Este documento es privado debido a limitaciones de derechos de autor.