Universidad de Costa Rica
  • Sobre Kérwá
  • Acceso Abierto
  • Cómo Depositar
  • Políticas
  • Contacto
    • español
    • English
  • English 
    • español
    • English
  • Login
View Item 
  •   Kérwá Home
  • Investigación
  • Salud
  • Medicina, ciencias biomédicas y salud pública
  • View Item
  •   Kérwá Home
  • Investigación
  • Salud
  • Medicina, ciencias biomédicas y salud pública
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Ancestry Informative Markers Clarify the Regional Admixture Variation in the Costa Rican Population

Thumbnail
View/Open
Ancestry Informative Markers (941.9Kb)
Date
2013-10-09
Author
Campos Sánchez, Rebeca
Raventós Vorst, Henriette
Barrantes Mesén, Ramiro
Metadata
Show full item record
Abstract
Study for the first time a random sample from all regions of the country with AIMS (Ancestry Informative Markers) to address the individual and regional admixture proportions. A sample of 160 male individuals was screened for 78 AIMs customized in a GoldenGate platform from Illumina. The genetic structure of Costa Rica’s population is complex, both by region and by individual, due to the admixture process that started during the 15th century and historical events thereafter. Previous studies have been done mostly on Amerindian populations and the Central Valley inhabitants using various microsatellites and mtDNA markers. Here, we study for the first time a random sample from all regions of the country with AIMS (Ancestry Informative Markers) to address the individual and regional admixture proportions. A sample of 160 male individuals was screened for 78 AIMs customized in a GoldenGate platform from Illumina. We observed that this small set of AIMs has the same power of hundreds of microsatellites and thousands of SNPs to evaluate admixture, with the benefit of reducing genotyping costs. This type of investigation is necessary to explore new genetic markers useful for forensic and genetic investigation. Our data showed a mean admixture proportion of 49.2% European, 37.8% Native American and 12.9% African, with a disproportionate admixture composition by region. In addition, when a fourth component, the Chinese, was included the proportions changed to 45.6% European, 33.5% Native American, 11.7% African, and 9.2% Chinese. The admixture trend is consistent among all regions (EUR>NAM>AFR) and individual admixture estimates vary broadly in each region. Though we did not find stratification in CRP, it is recommended to evaluate gene admixture in future genetic studies of Costa Rica, especially for the Caribbean region as it contains the largest proportion of African ancestry (30.9%).
URI
http://hdl.handle.net/10669/9190
http://digitalcommons.wayne.edu/humbiol/
artículo (arbitrado). Universidad de Costa Rica, Centro de Investigación en Biología Celular y Molecular, 2013
 
Collections
  • Medicina, ciencias biomédicas y salud pública [1372]



  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
  • Repositorio de Fotografías
  • Colección de videos de UPA-VAS
  • Sitios recomendados

  • Buscador regional de LA Referencia
  • Buscador del Open ROAR
  • Scientific Electronic Library Online (SciELO)
  • Directory of Open Access Journals (DOAJ)
  • Redalyc
  • Redes sociales

  • facebook.com/repositoriokerwa
  • @Ciencia_UCR
  • Sobre Kérwá
  • Acceso Abierto
  • Cómo depositar
  • Políticas
Contact Us | Send Feedback
Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
Universidad de Costa Rica
 

 

Browse

All of KérwáCommunities & CollectionsTitlesAuthorsSubjectsProcedenceTypeThis CollectionTitlesAuthorsSubjectsProcedenceType

My Account

LoginRegister

  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
  • Repositorio de Fotografías
  • Colección de videos de UPA-VAS
  • Sitios recomendados

  • Buscador regional de LA Referencia
  • Buscador del Open ROAR
  • Scientific Electronic Library Online (SciELO)
  • Directory of Open Access Journals (DOAJ)
  • Redalyc
  • Redes sociales

  • facebook.com/repositoriokerwa
  • @Ciencia_UCR
  • Sobre Kérwá
  • Acceso Abierto
  • Cómo depositar
  • Políticas
Contact Us | Send Feedback
Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
Universidad de Costa Rica