Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations
Fecha
2013-05-28Autor
Zavala, Juan Manuel
Dassori, Albana
Escamilla, Michael
Raventós Vorst, Henriette
Nicolini Sánchez, José Humberto
Ontiveros Sánchez de la Barquera, Jose Alfonso
Jerez, Álvaro
Contreras Rojas, Javier
Ramírez, Mercedes
Contreras, Salvador
Flores, Deborah
Leach, Robin J.
Armas, Regina
González, S. D.
Metadatos
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Some of the most
consistent findings have been in variants located in the ANK3
(ankyrin-G) gene located on chromosome 10q. Schultz et al.4
found that BP risk alleles in ANK3, rs9804190 and
rs10994336, contributed independently to BP with no significant
marker–marker interaction. we
have designed a family-based association study to evaluate
single-nucleotide polymorphisms (SNPs) spanning the ANK3
gene, including GWAS-significant SNPs rs9804190 and
rs10994336, in 215 Latino pedigrees with reported ancestry
from Mexico or Central America. All study participants were
diagnosed using Diagnostic and Statistical Manual of
Mental Disorders (DSM)-IV criteria using a best-estimation
consensus procedure as previously described.7 Of the
929 individuals in this study, 466 were diagnosed with BPI
and 16 were diagnosed with SABP.
External link to the item
10.1038/tp.2013.40
comunicación--Universidad de Costa Rica, Centro de Investigación en Biología Celular y Molecular, 2013