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Vertical Transmission in a Two-Strain Model of Dengue Fever

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Murillo, David
Holechek, Susan A.
Murillo, Anarina L.
Sánchez Peña, Fabio Ariel
Castillo Chávez, Carlos

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Abstract

The role of vertical transmission in vectors has rarely been addressed in the study of dengue dynamics and control, in part because it was not considered a critical population-level factor. In this paper, we apply the pioneering model- ing ideas of Ross and MacDonald, motivated by the context of the 2000–2001 dengue outbreak in Peru, to assess the dynamics of multi-strain competition. An invading strain of dengue virus (DENV-2) from Asia rapidly circulated into Peru eventually displacing DENV-2 American. A host-dengue model that con- siders the competing dynamics of these two DENV-2 genotypes, the resident or the American type and the invasive more virulent Asian strain, is introduced and analyzed. The model incorporates vertical transmission by DENV-2 Asian a potentially advantageous trait. Conditions for competitive exclusion of dengue strains are established. The model is used to show that lower transmission rates of DENV-2 Asian are sufficient for displacing DENV-2 American in the presence of vertical transmission.

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Modelo matemático, Modelos epidémicos, Matemática aplicada, Dengue, Transmisión vertical, Vector-host model, Epidemiology, Vertical transmission, Peru, 616.921 Fiebre de dengue

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https://www.tandfonline.com/doi/abs/10.1080/23737867.2014.11414484

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