Effect on cell growth, viability and migration of geraniol and geraniol-containing essential oil from Lippia alba (Verbenaceae) on gastric carcinoma cells
artículo original
Fecha
2021Autor
Ortiz Chaves, Natalia
Jiménez, María Fernanda
Chaverri Chaverri, Carlos
Cicció Alberti, José Francisco
Díaz Oreiro, Cecilia
Metadatos
Mostrar el registro completo del ítemResumen
Natural products used to treat cancer, or as leads for the development of preventive and co-adjuvant treatment strategies, are still a current approach. We studied the effect of essential oils
from the medicinal plant Lippia alba on tumor cell lines and observed that geraniol-rich citral
chemotype was the most effective, especially for breast and gastric carcinoma. Two main components of these essential oils, geraniol and limonene, were tested on gastric cancer cells, evidencing
that geraniol was significantly more effective inducing cytotoxicity. The activity of geraniol on AGS
cells was partially due to growth inhibition and we observed that some metastatic gastric cancer
cells were also sensitive to this compound. The effect of geraniol on growth inhibition was not
recovered by the addition of mevalonolactone, suggesting independence of isoprenylation. A
partial inhibitory effect of geraniol was also observed on AGS migration, making it potentially
effective to control invasive tumor behavior.
External link to the item
10.1080/10412905.2021.1975576Colecciones
- Química [360]