Epidemiology of human rotavirus types 1 and 2 as studied by enzyme-linked immunosorbent assay
artículo original
Date
1978-11-23Author
Yolken, Robert H.
Wyatt, Richard G.
Hisses, George
Brandt, Carld
Rodríguez, William J.
Wha Kim, Hyun
Parrot, Robert H.
Urrutia, Juan José
Mata Jiménez, Leonardo
Greenberg, Harry B.
Kapikian, Albert Z.
Chanock, Robert M.
Metadata
Show full item recordAbstract
To determine the relative importance of two known serotypes of human rotavirus, we developed an enzyme-linked immunosorbent assay to differentiate serotype-specific rotavirus antigen and antibody. Using this technic, we studied the epidemiology of the two serotypes in acute gastroenteritis. Seventy-seven
per cent of 414 rotavirus isolates were Type 2, and the remainder were Type 1. The serotype distribution was similar in specimens from children in Washington D.C., and other parts of the world. Seroepidemiological studies revealed that most children living in the Washington, D.C., area acquired antibody to both types by the age of two years. An analysis of children who were reinfected indicated that sequential infections usually involved different serotypes and that illness caused by one serotype did not provide resistance to illness caused by the other serotype. These results suggest that, to be completely effective, a vaccine must provide resistance to both serotypes
External link to the item
10.1056/NEJM197811232992103
artículo (arbitrado) -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 1978
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- Microbiología [1171]