Phosphatidylinositol 3-Kinase/Akt Pathway Targets Acetylation of Smad3 through Smad3/CREB-binding Protein Interaction: Contribution to transforming growth factor 1-induced epstein-barr virus reactivation
artículo original
Fecha
2009-09-04Autor
Oussaief, Lassad
Hippocrate, Aurélie
Ramírez Mayorga, Vanessa
Rampanou, Aurore
Zhang, Wei
Meyers, David
Cole, Philip
Khelifa, Ridha
Joab, Irène
Metadatos
Mostrar el registro completo del ítemResumen
Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor 1 (TGF- 1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF- 1-induced ZEBRA expression and enabled Smad3, a mediator of TGF- 1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF- 1-induced ZEBRA expression.
External link to the item
10.1074/jbc.M109.036483
Artículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2009. Este documento es privado debido a limitaciones de derechos de autor.
Colecciones
- Microbiología [1171]