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Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica
(2019)
The genus Porthidium includes nine pitviper species inhabiting Mexico, Central America, and northern South
America. Porthidium porrasi is a species endemic to the Southwest of Costa Rica, for which no information on ...
First look into the venom of Roatan Island´s critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom
(2019)
A proteomic and toxicological study of the venom from one specimen of Micrurus ruatanus, a critically endangered
coral snake species endemic to Roatan Island, Honduras, was carried out. Immunorecognition and
neutralization ...
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
(2019)
A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms,
responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering
...
Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): composition, biochemical activities and in vivo toxicity for potential prey
(2019)
In this study, we characterize the venom of Centruroides edwardsii, one of the most abundant scorpions in urban
and rural areas of Costa Rica, in terms of its biochemical constituents and their biological activities. C. ...
Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)
(2019)
The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease,
proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In
this context, ...
Enzymatic labelling of venom phospholipase A2 toxins
(2019)
Almost all animal venoms contain secretory phospholipases A2 (PLA2s), 14 kDa disulfide-rich enzymes that
hydrolyze membrane phospholipids at the sn-2 position, releasing lysophospholipids and fatty acids. These
proteins, ...
A secreted phospholipase A2 induces formation of smooth muscle foam cells which trans-differentiate to macrophage-like state
(2019)
Vascular smooth muscle cells (VSMCs) loaded with lipid droplets (LDs) are markers of
atherosclerosis. In this disease, inflammatory Group IIA-secreted phospholipase A2s (GIIA sPLA2s)
are highly expressed in VSMCs, but ...
Cloning, purification and characterization of nigrelysin, a novel actinoporin from the sea anemone Anthopleura nigrescens
(2019)
Actinoporins constitute a unique class of pore-forming toxins found in sea anemones that being secreted
as soluble monomers are able to bind and permeabilize membranes leading to cell death. The interest in
these proteins ...
Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro
(2019)
non-buthid venoms, for which knowledge is scarce. In this work, we characterized the venom of a Diplocentridae
species, Didymocentrus krausi, a small fossorial scorpion that inhabits the Tropical Dry Forest of Central ...
New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America
(2019)
Micrurus is a monophyletic genus of venomous coral snakes of the family Elapidae. The ~80 recognized species
within this genus are endemic to the Americas, and are distributed from southeastern United States to ...