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Primary structures and partial toxicological characterization of two phospholipases A2 from Micrurus mipartitus and Micrurus dumerilii coral snake venoms 

Rey Suárez, Paola; Núñez Rangel, Vitelbina; Saldarriaga Córdoba, Mónica María; Lomonte, Bruno (2017-06)
Snake venom phospholipases A2 (PLA2) share high sequence identities and a conserved structural scaffold, but show important functional differences. Only a few PLA2s have been purified and characterized from coral snake ...
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Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis 

Sanz, Libia; Escolano, José; Ferretti, Massimo; Biscoglio, Mirtha J.; Rivera, Elena; Crescenti, Ernesto J.; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Calvete Chornet, Juan José (2008-04-30)
We report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta (South American Bushmaster) and L. stenophrys (Central American Bushmaster), and compare the toxin ...
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Determinación cuantitativa de la actividad lítica del complemento sérico (CH50) en adultos costarricenses 

Mata, Eugenia; Lomonte, Bruno (1986)
En el presente trabajo se estandariza un método simple y cuantitativo para la determinación de la actividad hemolítica (CH5O) del complemento sérico. Con este método, se evalúa los niveles de complemento en una muestra ...
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A secreted phospholipase A2 induces formation of smooth muscle foam cells which trans-differentiate to macrophage-like state 

Giannotti, Karina Cristina; Weinert, Sönke; Viana, Mariana Nascimento; Leiguez, Elbio; Araujo, Thaís L. S.; Laurindo, Francisco R. M.; Lomonte, Bruno; Braun Dullaeus, Rüdiger; Teixeira, Catarina de Fátima (2019)
Vascular smooth muscle cells (VSMCs) loaded with lipid droplets (LDs) are markers of atherosclerosis. In this disease, inflammatory Group IIA-secreted phospholipase A2s (GIIA sPLA2s) are highly expressed in VSMCs, but ...
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Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead 

Solano Trejos, María Gabriela; Pla Ferrer, Davinia; Herrera Vega, María; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Villalta Arrieta, Mauren; Sánchez Brenes, Andrés; Sanz, Libia; Lomonte, Bruno; León Montero, Guillermo; Calvete Chornet, Juan José; Gutiérrez, José María (2017-05)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous ...

Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America 

Calvete Chornet, Juan José; Sanz, Libia; Cid, Pedro; De La Torre, Pilar; Flores Díaz, Marietta; Dos Santos, María Cristina; Borges, Adolfo; Bremo, Adolfo; Angulo Ugalde, Yamileth; Lomonte, Bruno; Alape Girón, Alberto; Gutiérrez, José María (2010)
We report a comparative venomic and antivenomic characterization of the venoms of newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of the subspecies cumanensis, durissus, ruruima, and ...

Individual expression patterns of myotoxin isoforms in the venom of the snake Bothrops Asper. 

Carmona Morera, Elena; Lomonte, Bruno (1992)
In order to investigate the distribution of myotoxin isoforms in the snake Bothrops asper, venoms from individual specimens were analyzed by a cathodic electrophoretic system for basic proteins under native conditions.The ...

Lys-49 phospholipases A2 as active enzymes for beta-arachidonoyl phospholipid bilayer membranes 

Yamaguchi, Yoko; Shimohigashi, Yasuyuki; Chiwata, Tsuyoshi; Tani, Ayako; Chijiwa, Takahisa; Lomonte, Bruno; Ohno, Motoroni (1997)
Phospholipases A2 containing Lys-49 have been reported to be extremely weak or inactive as enzyme. We have recently shown that basic proteins I and II (BP-I and BP-II), Lys- 49-PLA2s isolated from the venom of Trimeresurus ...
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Phospholipase A2 myotoxins from Bothrops snake venoms [Artículo de revisión] 

Gutiérrez, José María; Lomonte, Bruno (1995-11)
Several myotoxins have been isolated from Bothrops snake venoms during the last 10 years. All of them are group II basic phospholipases A2, although some lack enzymatic activity (i.e. Lys-49 variants). These myotoxins ...

Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2 

Casais e Silva, Luciana Lyra; Teixeira, Catarina de Fátima; Lebrun, Ivo; Lomonte, Bruno; Alape Girón, Alberto; Gutiérrez, José María (2016-08-26)
The venom of Micrurus lemniscatus, a coral snake of wide geographical distribution in South America, was fractionated by reverse-phase HPLC and the fractions screened for phospholipase A2 (PLA2) activity. The major component ...
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Lomonte, Bruno (355)
Gutiérrez, José María (197)Angulo Ugalde, Yamileth (60)Calvete Chornet, Juan José (55)Fernández Ulate, Julián (47)Sanz, Libia (38)Sasa Marín, Mahmood (23)Laustsen, Andreas Hougaard (22)Rucavado Romero, Alexandra (22)Díaz Oreiro, Cecilia (17)... View MoreTypeartículo científico (336)capítulo de libro (9)revista de divulgación (2)artículo de revisión (1)editorial (1)libro (1)otros (1)patente (1)preprint (1)tesis de doctorado (1)... View MoreProcedenceVicerrectoría de Investigación (355)Vicerrectoría de Docencia (58)... View MoreHas File(s)Yes (348)No (7)

  • Repositorios universitarios

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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.