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Seco-manool and other constituents from fleischmannia microstemon
(1988-01)
The aerial parts of Fleischmannia microstemon afforded in addition to sesamin and two clerodanes, ent-manoyl oxide and two derivatives of the latter, one a 6β-acetoxy derivative and the other a seco-labdane. From F. pratensis ...
Separation of crude plant extracts with high speed CCC for primary screening in drug discovery
(2001)
High speed countercurrent chromatography (HSCCC) was used
in a pre-fractionation pilot study to improve the quality of crude
plant samples for primary screening in drug discovery efforts. The
methanol ...
The Combined Use of Alphavirus Replicons and Pseudoinfectious Particles for the Discovery of Antivirals Derived from Natural Products
(2015)
Alphaviruses are a prominent class of reemergent pathogens due to their globally expanding ranges, potential for lethality, and possible use as bioweapons. The absence of effective treatments for alphaviruses highlights ...
Identification of polyphenols from antiviral Chamaecrista nictitans extract using high-resolution LC–ESI–MS/MS
(2014)
Chamaecrista nictitans (L) extract possesses antiviral properties; it acts against the herpes simplex virus, and this may be attributed to its constituent phenolics. Here, high-resolution LC–ESI–MS/MS is used to identify ...
Ent-clerodane derivatives and other constituents from representatives of the subgenus ageratina
(1989)
Ageratina ixiocladon afforded several p-hydroxyacetophenone derivatives and diterpenes including six new ent-clerodanes. Two further species, which are also placed in the subgenus Ageratina, gave p-hydroxyacetophenone ...
Screening of Latin American Plants for Cytotoxic Activity
(2006)
The SRB cytotoxicity assay was used to screen plant extracts, in a collaborative multinational OAS project involving Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua and Panama, against breast (MCF-7), lung ...
Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor
(2013)
Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell ...
Empleo de técnicas y materiales biológicos en la búsqueda de productos activos contra la malaria
(2001)
Se describen los métodos empleados en el estudio del efecto de extractos de insectos preparados en el Instituto Nacional de Biodiversidad de Costa Rica, sobre un tipo de malaria murina producida por el Plasmodium bergheim. ...
Bioactivity of prenylated hydroxybenzoic acids from Piper garagaranum C. DC
(2022)
A bio-assay guided fractionation of Piper garagaranum C. DC. led to the isolation of two prenylated hydroxybenzoic
acids (1-2) with anti-inflammatory and cytotoxic activities. The anti-inflammatory action was determined
in ...
Naphthalenones and Isocoumarins from a Costa Rican Fungus Xylariaceae sp. CR1546C
(2014)
A new naphthalenone, (R)-4,6,8-trihydroxy-3,4-dihydro-1(2H)-naphthalenone and a new isocoumarin, 6,8-dihydroxy-(3R)-(2-oxopropyl)-3,4-dihydroisocoumarin, together with eight related known compounds were isolated from the ...