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β-Carboline monoterpenoid glucosides from Palicourea adusta
(1999)
Lyaloside, a monoterpenoid glucoindole alkaloid, was isolated from the leaves of Palicourea adusta together with a mixture of its hydroxycinnamic acid derivatives, (E)-O-(6′)-cinnamoyl-4″-hydroxy-3″-methoxy-lyaloside and ...
Study of the diversity of culturable actinomycetes in the North Pacific and Caribbean coasts of Costa Rica
(2009)
In this study, 137 actinomycetes were isolated from subtidal marine sediments in the North Pacific and Caribbean coasts of Costa Rica. Bioinformatics analysis of the 16S rRNA gene sequences assigned the isolates to 15 ...
Alkaloid contents in members of Lycopodiales
(2001)
The composition of alkaloids in fifteen species that belong to the Lycopodiales, which grow wild in Costa Rica were analysed by gas chromatography coupled with mass spectrometry. Several alkaloids were identified, ...
Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis
(2014)
Siderophores are high-affinity iron chelators produced by microorganisms and frequently contribute to the virulence of human pathogens. Targeted inhibition of the biosynthesis of siderophores staphyloferrin B of Staphylococcus ...
Adipostatins E-J, new potent antimicrobials identified as inhibitors of coenzyme-A biosynthesis
(2020-01)
Phosphopantetheine is a key structural element in biological acyl transfer reactions found embedded within coenzyme A (CoA). Phosphopantothenoylcysteine synthetase (PPCS) is responsible for installing a cysteamine group ...
Biodiversity Prospecting: The INBio Experience
(2004)
Bioprospecting is defined as the systematic search for genes, compounds, designs, and organisms that might have a potential economic use and might lead to a product development. In 1991, Costa Rica's National Institute of ...
Germacranolides from Mikania guaco
(2001-03)
Fourteen novel sesquiterpene lactones of the germacranolide type have been isolated from the aerial parts of Mikania guaco: six costunolide, two melampolide and six germacra-4-trans,10(14),11(13)-trien-12,6α-olide derivatives. ...
Clibadiolide, a sesquiterpene lactone esterified with a homoditerpene from Clibadium pittierii
(1988)
The aerial parts of Clibadium pittierii afforded in addition to known melampolides two new ones, one being esterified with a homoditerpenic acid and the homoditerpenic acid itself. The structures were elucidated by high ...
Screening of Latin American plants for antiparasitic activities against malaria,Chagas disease, and leishmaniasis
(2010)
In order to explore rationally the medical potential of the plant biodiversity of the Central and South American region as a source of novel antiparasitic molecules, a multinational Organization of American States (OAS) ...
Seco-manool and other constituents from fleischmannia microstemon
(1988-01)
The aerial parts of Fleischmannia microstemon afforded in addition to sesamin and two clerodanes, ent-manoyl oxide and two derivatives of the latter, one a 6β-acetoxy derivative and the other a seco-labdane. From F. pratensis ...