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Las mutaciones inestables, nuevo reto para el consejo genético de enfermedades hereditarias
(Revista de Biología Tropical 52 (3) 491-499, 2004)Las mutaciones inestables constituyen un tipo de alteración genética descubierta en Ia década de los noventa. En condiciones normales, regiones especificas de los genes estan constitudas por repeticiones de una aucencia ... -
Mutaciones inestables: causa de algunas enfermedades neurológicas hereditarias
(1999-06)Las mutaciones inestables o amplificación de tripletas constituyen un tipo de alteración genética descubierto durante la última década. En condiciones normales, regiones específicas de algunos genes están constituidas por ... -
Mutagénesis ambiental y el use de biomarcadores para predecir el riesgo de cáncer
(Revista de Biología Tropical 52(3) p.585-590, 2004-12-14)La mutagénesis ambiental o genética toxicológica es una disciplina que tiene como objetivo estudiar el daño genético que conduce a mutaciones, producido por agentes físicos, químicos y biológicos, identificar estos agentes, ... -
Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance
(2021-07)Snakebite envenoming is a neglected tropical disease that may claim over 100,000 human lives annually worldwide. Snakebite occurs as the result of an interaction between a human and a snake that elicits either a defensive ... -
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
(2021-12-17)We hypothesize that dosage compensation of critical genes arises from systems- level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics ... -
Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica
(1989)The mode of action of a basic myotoxin isolated from Bothrops nummifer venom was studied. This myotoxin is a basic polypeptide of 13,000 mol.wt, with a high content of lysine and aspartate, as well as of hydrophobic amino ... -
Myotonic dystrophy type 1 (DM1) clinical subtypes and CTCF site methylation status flanking the CTG expansion are mutant allele length-dependent
(2021)Myotonic dystrophy type 1 (DM1) is a complex disease with a wide spectrum of symptoms. The exact relationship between mutant CTG repeat expansion size and clinical outcome remains unclear. DM1 congenital patients (CDM) ... -
Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation
(2005-09-01)Lys49 phospholipase A2 (PLA2) homologues are myotoxic proteins devoid of catalytic activity. Their toxic determinants map to the C-terminal region 115–129, which plays an effector role in membrane damage. The dimeric state ... -
Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu
(2000-08)Venoms from eight Bothrops spp. were fractionated by ion-exchange chromatography on CM-Sepharose at pH 8.0 for the purification of myotoxins. Chromatographic profiles showed differences regarding myotoxic components among ... -
Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2
(1991)A basic, dimeric myotoxic protein, myotoxin II, purified from Bothrops asper venom has a similar molecular weight and is immunologically cross-reactive with antibodies raised to previously isolated B. asper phospholipases ... -
Myotoxin-neutralizing peptides
(2018-03-27)The present invention relates to polypeptides having myotoxin-neutralizing properties and their use for treatment of envenomation. The present invention further relates to methods for neutralizing a venom using the polypeptide ... -
N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils
(2016-06)Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ... -
N-terminal peptide of myotoxin II from Bothrops asper venom enhances the activity of endothelin converting enzyme and neprilysin
(2016)Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here we report, the discovery ... -
National cancer registry, 1980-1983
(1988)Legislation making cancer a notifiable disease was introduced in Costa Rica in 1976. At the same time, a National Tumour Registry was established, and collection of data commenced in March 1977. The aims of the National ... -
National Health and Social Development in costa Rica: A Case Study of Intersectorial Action
(1988)Presenta el escenario sociopolítico de Costa Rica: historia, población, terreno, situación política; militarismo en América Central; situación económica; indicadores de salud y socioeconómicos en América Central; perfiles ... -
Natural history of Giardia infection of infants and children in rural Guatemala and its impact on physical growth
(1986-03)Longitudinal data on Giardia excretion, diarrheal disease, and physical growth during the first 3 yr of life collected more than 20 yr ago in 45 Guatemalan children were analyzed. This report describes the natural history ... -
Natural history of rotavirus infection in the children of Santa Maria Cauque
(Prog Food Nutr Sci 7 p. 167-177, 1983)A prospective observation of 45 cohort children from birth to three years of age permitted the collection of 5689 weekly stool specimens, along with frequent morbidity, dietary and growth data. Specimens tested by the ... -
Natural history of viruses of the intestine in contrasting ecosystems: implications for health
(1987)Many different viruses have the capacity for infecting and replicating in micro-habitats of the intestinal tract. Eons of interaction between intestinal viruses and the intestinal mucosa have lead to a variety of ... -
Necesidades educativas de autocuidado de las personas con diagnóstico de cáncer en tratamiento de oxaliplatino en el Hogar de Paso Resurgir
(2021-01-08)Introducción: El cáncer constituye uno de los principales problemas de salud que afecta a la población en general, cuya aparición se ha visto incrementada en las últimas décadas. Dicha enfermedad es tratada con diversos ...