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Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America 

Calvete Chornet, Juan José; Sanz, Libia; Cid, Pedro; De La Torre, Pilar; Flores Díaz, Marietta; Dos Santos, María Cristina; Borges, Adolfo; Bremo, Adolfo; Angulo Ugalde, Yamileth; Lomonte, Bruno; Alape Girón, Alberto; Gutiérrez, José María (2010)
We report a comparative venomic and antivenomic characterization of the venoms of newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of the subspecies cumanensis, durissus, ruruima, and ...

Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom 

Gutiérrez, José María; Sanz, Libia; Escolano, José; Fernández Ulate, Julián; Lomonte, Bruno; Angulo Ugalde, Yamileth; Rucavado Romero, Alexandra; Warrell, David A.; Calvete Chornet, Juan José (2008-10)
The venom proteomes of the snakes Bothrops caribbaeus and Bothrops lanceolatus, endemic to the Lesser Antillean islands of Saint Lucia and Martinique, respectively, were characterized by reversephase HPLC fractionation, ...
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Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis 

Sanz, Libia; Escolano, José; Ferretti, Massimo; Biscoglio, Mirtha J.; Rivera, Elena; Crescenti, Ernesto J.; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Calvete Chornet, Juan José (2008-04-30)
We report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta (South American Bushmaster) and L. stenophrys (Central American Bushmaster), and compare the toxin ...
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Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper 

Pérez, Aida Verónica; Rucavado Romero, Alexandra; Sanz, Libia; Calvete Chornet, Juan José; Gutiérrez, José María (2008-01)
A serine proteinase with thrombin-like activity was isolated from the venom of the Central American pit viper Bothrops asper. Isolation was performed by a combination of affinity chromatography on aminobenzamidine-Sepharose ...

Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism 

Núñez Rangel, Vitelbina; Cid, Pedro; Sanz, Libia; De La Torre, Pilar; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Calvete Chornet, Juan José (2009-11-02)
The venom proteomes of Bothrops atrox from Colombia, Brazil, Ecuador, and Perú were characterized using venomic and antivenomic strategies. Our results evidence the existence of two geographically differentiated venom ...

Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics 

Gutiérrez, José María; Solano Trejos, María Gabriela; Pla Ferrer, Davinia; Herrera Vega, María; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Sanz, Libia; Lomonte, Bruno; Calvete Chornet, Juan José; León Montero, Guillermo (2013-07)
The assessment of the capacity of antivenoms to neutralize the lethal activity of snake venoms is the gold standard in the preclinical analysis of antivenom efficacy, and is routinely performed by manufacturers and quality ...

Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae) 

Fernández Ulate, Julián; Alape Girón, Alberto; Angulo Ugalde, Yamileth; Sanz, Libia; Gutiérrez, José María; Calvete Chornet, Juan José; Lomonte, Bruno (2011-01-31)
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was analyzed by a “venomics” approach. Nearly 50 venom peaks were resolved by RP-HPLC, revealing a complex protein composition. Comparative ...

Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses 

Villalta Arrieta, Mauren; Pla Ferrer, Davinia; Yang, Su Lin; Sanz, Libia; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Chen, Pei Yu; Herrera Vega, María; Estrada Umaña, Ricardo; Cheng, Ya Fen; Lee, Cheng Dow; Cerdas Solís, Maykel; Chiang, Jen Ron; Angulo Ugalde, Yamileth; León Montero, Guillermo; Calvete Chornet, Juan José; Gutiérrez, José María (2012-10-22)
The proteomes of the venoms of the snakes Viridovipera stejnegeri and Protobothrops mucrosquamatus from Taiwan were characterized by N-terminal sequencing, MALDI-TOF mass fingerprinting, and collision-induced dissociation ...

Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches 

Petras, Daniel; Sanz, Libia; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Solano Centeno, Daniela; Vargas Arroyo, Mariángela; León Montero, Guillermo; Warrell, David A.; Theakston, R. David G.; Harrison, Robert A.; Durfa, Nandul; Nasidi, Abdulsalami; Gutiérrez, José María; Calvete Chornet, Juan José (2011)
Venomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica, and N. pallida revealed similar compositional trends. The high content of cytotoxins and PLA2s may account for the extensive tissue ...
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Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus 

Durban, Jordi; Pérez, Alicia; Sanz, Libia; Gómez Argüello, Aarón; Bonilla Murillo, Fabián; Rodríguez Arguedas, Santos; Chacón Gutiérrez, Danilo; Sasa Marín, Mahmood; Angulo Ugalde, Yamileth; Gutiérrez, José María; Calvete Chornet, Juan José (2013)
Background Understanding the processes that drive the evolution of snake venom is a topic of great research interest in molecular and evolutionary toxinology. Recent studies suggest that ontogenetic changes in venom ...
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Calvete Chornet, Juan José (76)
Gutiérrez, José María (57)Sanz, Libia (51)Lomonte, Bruno (43)Angulo Ugalde, Yamileth (23)Pla Ferrer, Davinia (23)Fernández Ulate, Julián (19)Sasa Marín, Mahmood (13)Herrera Vega, María (9)León Montero, Guillermo (9)... View MoreTypeartículo científico (72)contribución a revista (2)capítulo de libro (1)preprint (1)ProcedenceVicerrectoría de Investigación (76)Vicerrectoría de Docencia (7)... View MoreHas File(s)Yes (76)

  • Repositorios universitarios

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