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The earless monitor lizard Lanthanotus borneensis – a venomous animal? 

Mebs, Dietrich; Lomonte, Bruno; Fernández Ulate, Julián; Calvete Chornet, Juan José; Mahlov, Kristin; Müller, Johannes; Köhler, Gunther; Zollweg, Michael (2021)
Based on its mandibular gland secretion, the earless monitor lizard, Lanthanotus borneensis, has been considered a venomous animal like other members of the Toxicofera group, including Heloderma. In the present study, the ...
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Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms 

Ghazaryan, Narine A.; Ghulikyan, Lusine; Kishmiryan, Arsen; Andreeva, Tatyana V.; Utkin, Yuri N.; Tsetlin, Victor I.; Lomonte, Bruno; Ayvazyan, Naira M. (Biochimica et Biophysica Acta - Biomembranes vol 1848: 463–468, 2015-02)
We describe the interaction of various phospholipases A2 (PLA2) from snake venoms of the family Viperidae (Macrovipera lebetina obtusa, Vipera ursinii renardi, Bothrops asper) with giant unilamellar vesicles (GUVs) composed ...

The Phospholipase A2 Homologues of Snake Venoms: Biological Activities and Their Possible Adaptive Roles 

Lomonte, Bruno; Angulo Ugalde, Yamileth; Sasa Marín, Mahmood; Gutiérrez, José María (2009)
A particular subgroup of toxins with phospholipase A2 (PLA2) structure, but devoid of this enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and known as the PLA2 homologues. Among ...
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Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-Secreted phospholipase A2 from snake venom 

Leiguez, Elbio; Giannotti, Karina Cristina; Moreira, Vanessa; Matsubara, Marcio Hideki; Gutiérrez, José María; Lomonte, Bruno; Rodríguez, Juan Pablo; Balsinde, Jesus; Teixeira, Catarina de Fátima (PLoS One 9(4):e93741, 2014-04-09)
The snake venom MT-III is a group IIA secreted phospholipase A2 (sPLA2) enzyme with functional and structural similarities with mammalian pro-inflammatory sPLA2s of the same group. Previously, we demonstrated that MT-III ...
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Half a century of research on Bothrops asper venom variation: biological and biomedical implications 

Mora Obando, Diana; Lomonte, Bruno; Pla Ferrer, Davinia; Guerrero Vargas, Jimmy; Ayerbe, Santiago; Gutiérrez, José María; Sasa Marín, Mahmood; Calvete Chornet, Juan José (2022)
Snake venoms are a complex biological mixture of proteins with or without enzymatic activity, peptides, and nucleotides, among other components. It is produced in specialized secretory glands located in the maxillary region, ...

Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene 

Alape Girón, Alberto; Flores Díaz, Marietta; Guillouard, Isabelle; Naylor, Claire E.; Titball, Richard; Rucavado Romero, Alexandra; Lomonte, Bruno; Basak, Ajit K.; Gutiérrez, José María; Cole, Steward T.; Thelestam, Mónica (2000-08)
Clostridium perfringens phospholipase C (PLC), also called α-toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered α-toxin variants harboring single ...
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Métodos de Investigación: destrezas básicas para el trabajo científico en las disciplinas biomédicas 

Lomonte, Bruno; Díaz Oreiro, Cecilia; Gutiérrez, José María; Moreno Robles, Edgardo (2020-10-01)
Esta obra didáctica nace con el objetivo de presentar a sus lectores una visión introductoria sobre el fenómeno científico actual, sus orígenes, su contexto costarricense, y posteriormente presentar las principales ...

Neutralization of the cytolytic and myotoxic activities of phospholipases A2 from Bothrops asper snake venom by glycosaminoglycans of the heparin/heparan sulfate family 

Lomonte, Bruno; Tarkowski, Andrej; Bagge, Ulf; Hanson, Lars Ake (1994)
Basic phospholipases A2 from the venom of Bothrops asper exhibit skeletal muscle damaging activity in vivo, and cytolytic activity to a variety of cell types in culture. Glycosaminoglycans of the heparin/heparan sulfate ...

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score 

Laustsen, Andreas Hougaard; Lohse, Brian; Lomonte, Bruno; Engmark, Mikael Gerling; Gutiérrez, José María (2015-09-15)
For more than 100 years, antivenoms have been produced by traditional methods of immunization of large mammals with mixtures of snake venoms (World Health Organization, 2010 and Gutiérrez et al., 2011). With the introduction ...
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South American snake venom proteins antigenically-related to Bothrops asper myotoxins. 

Lomonte, Bruno; Furtado, María de Fátima; Rovira Rodríguez, María Elena; Carmona Morera, Elena; Rojas Céspedes, Gustavo; Aymerich Blen, Rodrigo; Gutiérrez, José María (1990)
the presence of proteins antigenically related to Bothrops asper myotoxins in various snake venoms, mainly from South America, was investigated by using poluclonal and monoclonal antibodies. 2. Myotoxin-like components ...
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