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Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice 

Lopes Ferreira, Mónica; Núñez, Javier; Rucavado Romero, Alexandra; Farsky, Sandra H. P.; Lomonte, Bruno; Angulo Ugalde, Yamileth; Moura Da Silva, Ana M.; Gutiérrez, José María (2001-02)
Stings by Thalassophryne nattereri are responsible for envenomation of fishermen in north-eastern Brazil. Its venom induces prominent local tissue damage, characterized by pain, oedema and necrosis. The pathogenesis of ...
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Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injection 

Patiño Llano, Arley Camilo; Quintana, Juan Carlos; Gutiérrez, José María; Rucavado Romero, Alexandra; Benjumea, Dora María; Pereañez, Jaime Andrés (2015)
Renealmia alpinia (Rottb.) MAAS, obtained by micropropagation (in vitro) and wild forms have previously been shown to inhibit some toxic activities of Bothrops asper snake venom if preincubated before injection. In this ...

Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage 

Gutiérrez, José María; Rucavado Romero, Alexandra (2000-09-10)
The biochemical characteristics of hemorrhagic metalloproteinases isolated from snake venoms are reviewed, together with their role in the pathogenesis of the local tissue damage characteristic of crotaline and viperine ...
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Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom 

Rucavado Romero, Alexandra; Henríquez, Mónica; García, Jonielle; Gutiérrez, José María (2008-12-01)
Snake venom metalloproteinases (SVMPs) play a prominent role in the local and systemic manifestations of viperid snakebite envenomations. Thus, the possibility of using metalloproteinase inhibitors in the treatment of these ...

Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation 

Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Gutiérrez, José María (2014-03-15)
The peptidomimetic hydroxamate metalloproteinase inhibitor batimastat (BB-94) was assessed for its ability to neutralize the systemic effects (lethality, hemorrhage and coagulopathy) induced by the venom of Bothrops asper, ...
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Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment 

Farsky, Sandra H. P.; Gonçalves, Luís Roberto de Camargo; Gutiérrez, José María; Correa, Adriana P.; Rucavado Romero, Alexandra; Gasque, Philippe; Tambourgi, Denise V. (2000)
The venom of the snake Bothrops asper, the most important poisonous snake in Central America, evokes an inflammatory response, the mechanisms of which are not well characterized. The objectives of this study were to ...

Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom 

Escalante Muñoz, Teresa; Núñez, Javier; Moura Da Silva, Ana M.; Rucavado Romero, Alexandra; Theakston, R. David G.; Gutiérrez, José María (2003-11-15)
Jararhagin is the most important hemorrhagic component in the venom of the snake Bothrops jararaca, a species of medical importance in South America. It is a P-III zinc-dependent metalloproteinase comprising catalytic, ...

Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu 

Pérez, Aida Verónica; Saravia Otten, Patricia; Rucavado Romero, Alexandra; Sant’Ana, Carolina D.; Soares, Andreimar Martins; Gutiérrez, José María (2007-06-01)
The local and systemic pathophysiological alterations induced by BjussuSP-I, a thrombin-like serine proteinase from the venom of the snake Bothrops jararacussu, were assessed in mice. BjussuSP-I induced a mild edema but ...

Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase 

Bernardes, Carolina P.; Menaldo, Danilo L.; Camacho Umaña, Erika; Rosa, José C.; Escalante Muñoz, Teresa; Rucavado Romero, Alexandra; Lomonte, Bruno; Gutiérrez, José María; Sampaio, Suely V.; Rosa, José C. (2013-03-27)
Bothrops pirajai snake venom was analyzed by a proteomic strategy. Proteins were separated by RP-HPLC, followed by SDS-PAGE, in-gel tryptic digestion, identification by MALDI-TOF/TOF mass spectrometry, and assignment to ...

Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture 

Saravia Otten, Patricia; Robledo, Bárbara; Escalante Muñoz, Teresa; Bonilla, Llira; Rucavado Romero, Alexandra; Lomonte, Bruno; Hernández, Rosario; Flock, Jan-Ingmar; Gutiérrez, José María; Gastaldello, Stefano (2013-02)
Introduction: Viperid snakebite envenomings are characterized by muscle necrosis and a deficient regenerative response. Methods: Homogenates from gastrocnemius muscles of mice injected with the venom of the snake Bothrops ...
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Rucavado Romero, Alexandra (69)
Gutiérrez, José María (64)Escalante Muñoz, Teresa (29)Lomonte, Bruno (22)Fox, Jay W. (12)Angulo Ugalde, Yamileth (7)Calvete Chornet, Juan José (7)Díaz Oreiro, Cecilia (7)León Montero, Guillermo (6)Chaves Mora, Fernando (5)... View MoreTypeartículo científico (67)capítulo de libro (2)ProcedenceVicerrectoría de Investigación (69)Vicerrectoría de Docencia (7)... View MoreHas File(s)Yes (69)

  • Repositorios universitarios

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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.