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Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms 

Segura Ruiz, Álvaro; Castillo, M. C.; Núñez Rangel, Vitelbina; Yarlequé, A.; Gonçalves, Luís Roberto de Camargo; Villalta Arrieta, Mauren; Bonilla, César; Herrera Vega, María; Fernández, M.; Yano, M. Y.; Araújo, H. P.; Boller, M. A. A.; León, P.; Sano Martins, I. S.; Gómez, A.; Fernández, Gil Patrick; Geoghegan, Patricia; Higashi, Hisako Gondo; León Montero, Guillermo; Gutiérrez, José María; Tintaya, Benigno (2010-11)
Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, ...

Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA 

Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Franceschi, Aida; Chaves Mora, Fernando; León Montero, Guillermo; Cury, Yara; Ovadia, Michael; Gutiérrez, José María (2000-11)
The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both ...

Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. 

Gutiérrez, José María; León Montero, Guillermo; Lomonte, Bruno (2003-07)
Parenteral administration of horse- and sheep-derived antivenoms constitutes the cornerstone in the therapy of envenomations induced by animal bites and stings. Depending on the type of neutralising molecule, antivenoms ...

Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom 

Olmedo, Hidekel; Herrera Vega, María; Rojas Sánchez, Leonardo; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Leiguez, Elbio; Teixeira, Catarina de Fátima; Estrada Umaña, Ricardo; Gutiérrez, José María; León Montero, Guillermo; Montero Villalobos, Mavis Lili (2014)
The adjuvanticity of aluminum hydroxide and calcium phosphate on the antibody response in mice towards the venom of the snake Bothrops asper was studied. It was found that, in vitro, most of the venom proteins are similarly ...

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms 

León Montero, Guillermo; Herrera Vega, María; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Gutiérrez, José María (2013-12-15)
Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments, purified from the plasma of animals immunized with snake venoms. Their therapeutic success lies in their ability to mitigate the progress ...

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus 

Sánchez Brenes, Andrés; Herrera Vega, María; Villalta Arrieta, Mauren; Solano Centeno, Daniela; Segura Ruiz, Álvaro; Lomonte, Bruno; Gutiérrez, José María; León Montero, Guillermo; Vargas Arroyo, Mariángela (2018-06)
The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom ...

Immune Response Towards Snake Venoms 

León Montero, Guillermo; Sánchez Céspedes, Laura Vanessa; Hernández, Andrés; Villalta Arrieta, Mauren; Herrera Vega, María; Segura Ruiz, Álvaro; Estrada Umaña, Ricardo; Gutiérrez, José María (2011)
The immune response involves a complex repertoire of innate and adaptive responses to foreign agents in the organism. The present review focuses on the immune response to snake venoms, including those occurring in snakebite ...

Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms 

Durán Blanco, Gina; Solano Blanco, María Gabriela; Gómez Argüello, Aarón; Cordero Vásquez, Daniel; Sánchez Sánchez, Adriana; Villalta Arrieta, Mauren; Sánchez Chaves, Melvin; Díaz Oreiro, Cecilia; Gutiérrez, José María; León Montero, Guillermo (2021-11)
The lethality neutralization assay in mice is the gold standard for the evaluation of the preclinical efficacy and specification fulfillment of snake antivenoms. However, owing to the animal suffering involved, this assay ...
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Caracterización proteómica y toxicológica del veneno de Crotalus pifanorum (viperidae) y evaluación de su uso como inmunógeno sobre la respuesta por anticuerpos contra co-inmunógenos y venenos de otros crótalos americanos 

Alfaro Chinchilla, Adriana (2019)
En Costa Rica se produce un antiveneno poliespecífico (PoliVal-ICP) usando como inmunógenos los venenos de las serpientes Bothrops asper, Crotalus simus y Lachesis stenophrys. Este antiveneno es capaz de neutralizar a la ...

Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions 

León Montero, Guillermo; Monge Monge, María; Rojas Umaña, Ermila; Lomonte, Bruno; Gutiérrez, José María (2001-06)
Whole IgG and F(ab′)2 equine-derived polyvalent (Crotalinae) antivenoms, prepared from the same batch of hyperimmune plasma, were compared in terms of neutralization of the lethal and defibrinating activities induced by ...
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AuthorLeón Montero, Guillermo (67)Gutiérrez, José María (56)Herrera Vega, María (38)Segura Ruiz, Álvaro (36)Villalta Arrieta, Mauren (27)Vargas Arroyo, Mariángela (25)Lomonte, Bruno (17)Angulo Ugalde, Yamileth (10)Estrada Umaña, Ricardo (10)Calvete Chornet, Juan José (9)... View MoreTypeartículo científico (62)tesis de maestría (3)capítulo de libro (1)patente (1)ProcedenceVicerrectoría de Investigación (67)Vicerrectoría de Docencia (8)... View MoreHas File(s)Yes (63)No (4)

  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
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  • Repositorio de Fotografías
  • Colección de videos de UPA-VAS
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  • Scientific Electronic Library Online (SciELO)
  • Directory of Open Access Journals (DOAJ)
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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.