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Mostrando ítems 261-270 de 358
Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper
(2009-12-01)
The isolation and study of individual snake venom components paves the way for a deeper
understanding of the pathophysiology of envenomings – thus potentially contributing to
improved therapeutic modalities in the clinical ...
Immunoenzymatic quantitation of antibodies to Bothrops asper myotoxins after polyvalent antivenom administration in mice.
(1992)
Two quantitative enzyme-immunoassays (EIA) for Bothrops asper myotoxin and anti-myotoxin antibodies, respectively, were utilized to study their in vivo distribution in mice (Swiss, 18 to 20 g). 2. After polyvalent antivenom ...
Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation
(PlosOne 2(10):e318, 2008-10-15)
Background: Envenomations by the snake Bothrops asper represent a serious medical problem in Central America and parts of South America. These envenomations concur with drastic local tissue pathology, including a prominent ...
Divergent functional profiles of acidic and basic phospholipases A2 in the venom of the snake Porthidium lansbergii lansbergii
(2016-09-01)
The Lansberg’s hognose pitviper, Porthidium lansbergii lansbergii, inhabits northern Colombia. A recent
proteomic characterization of its venom (J. Proteomics [2015] 114, 287e299) revealed the presence of
phospholipases ...
Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer
(1986)
A myotoxin from the venom of the snake Bothrops nummifer was purified to homogeneity by ion-exchange chromatography on CM-Sephadex. The toxin is a basic dimer with a subunit molecular weight of 16,000, as estimated by ...
Isolation, characterization and molecular cloning of AnMIP, a new α-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae)
(2007)
A new phospholipase A2 (PLA2)-inhibitory protein was isolated from the plasma of Atropoides nummifer, a crotaline snake from Central
America. This inhibitor was named AnMIP, given its ability to neutralize the activity ...
Host response to Bothrops asper snake venom: analysis of edema formation, inflammatory cells, and cytokine release in a mouse model
(1993)
As part of tle characterization of the host reactivity to the venom of Bothrops
asper, we investigated the inflammatory responses in the mouse footpad model.
The subcutaneously iniected venom induced a rapid increase of ...
Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii
(2008-04-30)
We report the comparative proteomic characterization of the venoms of two related neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side-striped palm pit viper) and B. schlegelii (eyelash ...
Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors
(2012-09)
Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s),
enzymes that have two independent evolutionary ...
Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations
(2007)
The therapy of snakebite envenomation has been based on the parenteral administration of animal-derived antivenoms. Despite the success of this treatment at reducing the impact of snakebite mortality and morbidity, mostly ...