Browsing Microbiología by Author "Quirós Barrantes, Steve"
Now showing items 1-7 of 7
-
A hybrid mathematical modeling approach of the metabolic fate of a fluorescent sphingolipid analogue to predict cancer chemosensitivity
Molina Mora, José Arturo; Kop Montero, Mariana; Quirós Fernández, Isaac; Quirós Barrantes, Steve; Crespo Mariño, Juan Luis; Mora Rodríguez, Rodrigo Antonio (2018-06)Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate ... -
Bactericidal and anti-endotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2
Santamaría Quesada, Carlos Manuel; Larios Ramos, Silda; Quirós Barrantes, Steve; Pizarro Cerdá, Javier; Gorvel, Jean Pierre; Lomonte, Bruno; Moreno Robles, Edgardo (2005)The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake Bothrops asper, have been ... -
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
Molina Mora, José Arturo; Quirós Barrantes, Steve; Kop Montero, Mariana; Mora Rodríguez, Rodrigo Antonio; Crespo Mariño, Juan Luis (2017)Sphingolipid (SL) signaling pathway is a complex biological system able to integrate different types of cellular stress signals related to induction of cell death pathways with special interest in cancer. This makes of ... -
Isolation, characterization and molecular cloning of AnMIP, a new α-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae)
Quirós Barrantes, Steve; Alape Girón, Alberto; Angulo Ugalde, Yamileth; Lomonte, Bruno (2007)A new phospholipase A2 (PLA2)-inhibitory protein was isolated from the plasma of Atropoides nummifer, a crotaline snake from Central America. This inhibitor was named AnMIP, given its ability to neutralize the activity ... -
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
Acón, Man Sai; Geiß, Carsten; Torres Calvo, Jorge; Bravo Estupiñan, Diana; Oviedo Blanco, Guillermo; Arias Arias, Jorge Luis; Rojas Matey, Luis Andres; Báez Villalobos, Edwin; Vásquez Vargas, Gloriana; Oses Vargas, Yendry; Guevara Coto, José Andrés; Segura Castillo, Andrés; Siles Canales, Francisco; Quirós Barrantes, Steve; Régnier Vigouroux, Anne; Mendes, Pedro; Mora Rodríguez, Rodrigo Antonio (2021-12-17)We hypothesize that dosage compensation of critical genes arises from systems- level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics ... -
Serum sexual steroid hormones and lipids in commercial broilers (Gallus domesticus) in Costa Rica
Holst Schumacher, Ileana; Quirós Barrantes, Steve; Zumbado Alpízar, Mario Ernesto; Ruiz Corella, Max A. (2010-09)The poultry-breeding industry worldwide has focused on the development of hybrids for meat or egg production. In Costa Rica, there is a popular belief that commercial broilers have a high growth rate because they are raised ... -
Sphingolipid pathway as a biosensor of cancer chemosensitivity: a proof of principle
Molina Mora, José Arturo; Mesén Porras, Susana; Quirós Fernández, Isaac; Kop Montero, Mariana; Rojas Céspedes, Andrea; Quirós Barrantes, Steve; Siles Canales, Francisco; Mora Rodríguez, Rodrigo Antonio (2022-12)Cancer is a complex genetic disease with reduced treatment alternatives due to tumor heterogeneity and drug multiresistance emergence. The sphingolipid (SL) metabolic pathway integrates different responses of cellular ...