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Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice 

Lopes Ferreira, Mónica; Núñez, Javier; Rucavado Romero, Alexandra; Farsky, Sandra H. P.; Lomonte, Bruno; Angulo Ugalde, Yamileth; Moura Da Silva, Ana M.; Gutiérrez, José María (2001-02)
Stings by Thalassophryne nattereri are responsible for envenomation of fishermen in north-eastern Brazil. Its venom induces prominent local tissue damage, characterized by pain, oedema and necrosis. The pathogenesis of ...

The Phospholipase A2 Homologues of Snake Venoms: Biological Activities and Their Possible Adaptive Roles 

Lomonte, Bruno; Angulo Ugalde, Yamileth; Sasa Marín, Mahmood; Gutiérrez, José María (2009)
A particular subgroup of toxins with phospholipase A2 (PLA2) structure, but devoid of this enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and known as the PLA2 homologues. Among ...

Phospholipase A2 enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis 

Bustillo, Soledad; García Denegri, María Emilia; Gay, Carolina; Van de Velde, Andrea C.; Acosta, Ofelia; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Leiva, Laura (2015-10-05)
Microvessel disruption leading to hemorrhage stands among the most dangerous consequences of envenomings by snakes of the family Viperidae. A PIII metalloproteinase (SVMP), balteragin, purified from the venom of the snake ...
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Antivenoms for Snakebite Envenomings 

Gutiérrez, José María; León Montero, Guillermo; Lomonte, Bruno; Angulo Ugalde, Yamileth (2011-10)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. Antivenoms are manufactured by immunizing animals, usually horses, with venoms from a single or several medically-relevant snake ...

Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro 

Lomonte, Bruno; Angulo Ugalde, Yamileth; Rufini, Stefano; Cho, Wonhwa; Giglio, José Roberto; Ohno, Motoroni; Daniele, José Julían; Geoghegan, Patricia; Gutiérrez, José María (1999-01)
A rapid in vitro cytolytic effect of some myotoxic phospholipases A2 (PLA2s) isolated from the venoms of Viperidae snakes has been previously described. This study was undertaken to investigate if cytolytic activity is a ...

Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: Toxicological and taxonomical insights 

Lomonte, Bruno; Rey Suárez, Paola; Tsai, Wan-Chih; Angulo Ugalde, Yamileth; Sasa Marín, Mahmood; Gutiérrez, José María; Calvete Chornet, Juan José (2012-02-16)
Within the Neotropical pit vipers, a lineage of primarily Middle American snake species referred to as the “Porthidium group” includes the genera Atropoides, Cerrophidion, and Porthidium. In this study, the venom proteomes ...

Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment. 

Lopes Ferreira, Mónica; Moura Da Silva, Ana M.; Piran Soares, Ana Amélia; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Farsky, Sandra H. P. (2002-08)
Accidents by Thalassophryne nattereri fish venom are characterised by severe local symptoms and signs including pain of fast onset, oedema and necrosis with impaired muscle regeneration. These effects have been related to ...

Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A2 homologue 

Angulo Ugalde, Yamileth; Olamendi Portugal, Timoteo; Alape Girón, Alberto; Possani, Lourival D.; Lomonte, Bruno (2002)
In order to analyze its structure–function relationships, the complete amino acid sequence of myotoxin II from Atropoides (Bothrops) nummifer from Costa Rica was determined. This toxin is a Lys49-type phospholipase A2 ...

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties 

Lizano González, Sergio; Angulo Ugalde, Yamileth; Lomonte, Bruno; Fox, Jay W.; Lambeau, Gérard; Lazdunski, Michel; Gutiérrez, José María (2000-03-15)
Myotoxic phospholipases A2 (PLA2s; group II) account for most of the muscle-tissue damage that results from envenomation by viperid snakes. In the venom of the Godman's viper (Cerrophidion godmani, formerly Bothrops godmani), ...

Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment 

Lomonte, Bruno; León Montero, Guillermo; Angulo Ugalde, Yamileth; Rucavado Romero, Alexandra; Núñez Rangel, Vitelbina (2009)
Interest in studies on the neutralization of snake venoms and toxins by diverse types of inhibitors is two-fold. From an applied perspective, results enclose the potential to be translated into useful therapeutic products ...
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Angulo Ugalde, Yamileth (68)
Lomonte, Bruno (59)Gutiérrez, José María (45)Calvete Chornet, Juan José (22)Sanz, Libia (17)León Montero, Guillermo (10)Fernández Ulate, Julián (9)Alape Girón, Alberto (7)Rucavado Romero, Alexandra (7)Herrera Vega, María (5)... View MoreTypeartículo científico (67)patente (1)ProcedenceVicerrectoría de Investigación (68)Vicerrectoría de Docencia (19)... View MoreHas File(s)Yes (66)No (2)

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