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Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice 

Lopes Ferreira, Mónica; Núñez, Javier; Rucavado Romero, Alexandra; Farsky, Sandra H. P.; Lomonte, Bruno; Angulo Ugalde, Yamileth; Moura Da Silva, Ana M.; Gutiérrez, José María (2001-02)
Stings by Thalassophryne nattereri are responsible for envenomation of fishermen in north-eastern Brazil. Its venom induces prominent local tissue damage, characterized by pain, oedema and necrosis. The pathogenesis of ...

Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper 

Escalante Muñoz, Teresa; Franceschi, Aida; Rucavado Romero, Alexandra; Gutiérrez, José María (2000-07-15)
Batimastat (BB-94), a synthetic hydroxamate peptidomimetic matrix metalloproteinase inhibitor, was tested for its ability to inhibit proteolytic and toxic effects induced by BaP1, a 24-kDa hemorrhagic metalloproteinase ...
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Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment 

Farsky, Sandra H. P.; Gonçalves, Luís Roberto de Camargo; Gutiérrez, José María; Correa, Adriana P.; Rucavado Romero, Alexandra; Gasque, Philippe; Tambourgi, Denise V. (2000)
The venom of the snake Bothrops asper, the most important poisonous snake in Central America, evokes an inflammatory response, the mechanisms of which are not well characterized. The objectives of this study were to ...

Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene 

Alape Girón, Alberto; Flores Díaz, Marietta; Guillouard, Isabelle; Naylor, Claire E.; Titball, Richard; Rucavado Romero, Alexandra; Lomonte, Bruno; Basak, Ajit K.; Gutiérrez, José María; Cole, Steward T.; Thelestam, Mónica (2000-08)
Clostridium perfringens phospholipase C (PLC), also called α-toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered α-toxin variants harboring single ...
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Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper 

Pérez, Aida Verónica; Rucavado Romero, Alexandra; Sanz, Libia; Calvete Chornet, Juan José; Gutiérrez, José María (2008-01)
A serine proteinase with thrombin-like activity was isolated from the venom of the Central American pit viper Bothrops asper. Isolation was performed by a combination of affinity chromatography on aminobenzamidine-Sepharose ...

Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage 

Gutiérrez, José María; Rucavado Romero, Alexandra (2000-09-10)
The biochemical characteristics of hemorrhagic metalloproteinases isolated from snake venoms are reviewed, together with their role in the pathogenesis of the local tissue damage characteristic of crotaline and viperine ...

Skin Pathology Induced by Snake Venom Metalloproteinase: Acute Damage, Revascularization, and Re-epithelization in a Mouse Ear Model 

Jiménez Álvarez, Natalia; Escalante Muñoz, Teresa; Gutiérrez, José María; Rucavado Romero, Alexandra (2008-10)
Viperid snakebite envenomation induces blistering and dermonecrosis. The pathological alterations induced by a snake venom metalloproteinase in the skin were investigated in a mouse ear model. Metalloproteinase BaP1, from ...

Proteomics of Wound Exudate in Snake Venom-Induced Pathology: Search for Biomarkers To Assess Tissue Damage and Therapeutic Success 

Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Shannon, John D.; Gutiérrez, José María; Fox, Jay W. (2011-02-10)
Tissue damage analysis by traditional laboratory techniques is problematic. Proteomic analysis of exudates collected from affected tissue constitutes a powerful approach to assess tissue alterations, since biomarkers ...

Efficacy of IgG and F(ab′)2 Antivenoms to Neutralize Snake Venom-induced Local Tissue Damage as Assessed by the Proteomic Analysis of Wound Exudate 

Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Shannon, John D.; Ayala Castro, Carla N.; Villalta Arrieta, Mauren; Gutiérrez, José María; Fox, Jay W. (2012)
Proteomic analysis of wound exudates represents a valuable tool to investigate tissue pathology and to assess the therapeutic success of various interventions. In this study, the ability of horse-derived IgG and F(ab0)2 ...

Neutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatment 

Lomonte, Bruno; León Montero, Guillermo; Angulo Ugalde, Yamileth; Rucavado Romero, Alexandra; Núñez Rangel, Vitelbina (2009)
Interest in studies on the neutralization of snake venoms and toxins by diverse types of inhibitors is two-fold. From an applied perspective, results enclose the potential to be translated into useful therapeutic products ...
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Rucavado Romero, Alexandra (69)
Gutiérrez, José María (64)Escalante Muñoz, Teresa (29)Lomonte, Bruno (22)Fox, Jay W. (12)Angulo Ugalde, Yamileth (7)Calvete Chornet, Juan José (7)Díaz Oreiro, Cecilia (7)León Montero, Guillermo (6)Chaves Mora, Fernando (5)... View MoreTypeartículo científico (67)capítulo de libro (2)ProcedenceVicerrectoría de Investigación (69)Vicerrectoría de Docencia (7)... View MoreHas File(s)Yes (69)

  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
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  • Colección de videos de UPA-VAS
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  • Scientific Electronic Library Online (SciELO)
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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.