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A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors
(2013-01-31)
IgG responses are crucial in antiviral defence and instrumental for the serodiagnosis of infections. Fcγ receptors (FcγRs), which recognize the Fc-part of IgG, differ regarding their IgG binding affinity, IgG subclass ...
Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines
(2006-04)
The inflammatory events induced by BaP1, a 22.7 kDa metalloproteinase isolated from Bothrops asper snake venom, were studied. BaP1 i.p. injection in mice induced a marked inflammatory cell infiltrate into peritoneal cavity ...
Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper
(1997-09-15)
A protein that neutralizes the biological activities of basic phospholipase A2 (PLA2) myotoxin isoforms from the venom of the snake Bothrops asper was isolated from its blood by affinity chromatography with Sepharose-immobilized ...
Immunochemical characterization and role in toxic activities of region 115-129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom
(1998-10)
The region 115–129 of myotoxin II, a catalytically inactive
Lys49 phospholipase A2, was previously shown to
constitute a heparin-binding site and to be involved in
its cytolytic action in vitro. An immunochemical ...
Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids
(2015-12-01)
Protein composition, toxicity, and neutralization of the venoms of Micrurus alleni and Micrurus mosquitensis, two sympatric monadal coral snakes found in humid environments of the Caribbean region of Costa Rica, were ...
Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs
(2005-12)
Caprylic acid purification of IgG, currently used in the manufacture of horse-derived antivenoms, was successfully adapted for the preparation of sheep and camel IgG. Sheep IgG had a molecular mass of approximately 150 ...
Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus)
(2017)
Adjuvant emulsions are widely used to enhance the antibody response of the animals used as immunoglobulin source for producing antivenoms. Usually, the adjuvant activity of emulsions is attributed both to their ability to ...
Estudio de asociación entre el gen candidato DISC1 y la psicosis en la población del Valle Central de Costa Rica
(2023-12-07)
Disrupted in Schizophrenia 1 (DISC1) es un gen originalmente identificado como
afectado por una translocación cromosómica en miembros de una familia escocesa
con una alta prevalencia de trastornos psiquiátricos. La ...
Paracoccidioidomicosis, consideraciones de una micosis desatendida
(2021-10-08)
El presente trabajo corresponde a una revisión bibliográfica sobre el estado del
conocimiento de las especies de Paracoccidioides spp. y los cuadros clínicos asociados a este
hongo. La revisión inicia con un marco histórico ...
Challenges detecting SARS-CoV-2 in Costa Rican domestic wastewater and river water
(2023-11-01)
This study presents the development of a SARS-CoV-2 detection method for domestic wastewater and river water in Costa Rica, a middle-income country in Central America. Over a three-year period (November to December 2020, ...