Microbiología
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Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib
(2023)Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A2 (PLA2) originally developed to control inflammatory cascades of diseases associated with high or dysregulated levels of endogenous PLA2. ... -
Vector-borne pathogens in dogs from Costa Rica: First molecular description of Babesia vogeli and Hepatozoon canis infections with a high prevalence of monocytic ehrlichiosis and the manifestations of co-infection
(2014)Infection with canine vector-borne pathogens was evaluated in dogs from four different regions of Costa Rica by PCR. Demographic data, clinical signs, packed cell volume values, and the presence of tick infestation were ... -
Acanthamoeba genotype T4 keratitis in a patient with Thygeson’s superficial punctate keratitis
(2017-01)A case of amoebic keratitis due to Acanthamoeba genotype T4 is reported. The patient is a 74-year old woman with Thygeson’s superficial punctate keratitis. Corneal scrapings were employed for the diagnosis, which included ... -
Isolation and molecular characterization of Acanthamoeba and Balamuthia mandrillaris from combination shower units in Costa Rica
(2014-08-19)Free living amoebae (FLA) are ubiquitous protozoa, which may behave as parasites under certain conditions. Four genera are recognized as causal agents of infections in humans and animals: Naegleria, Sappinia, Acanthamoeba ... -
Amebas de vida libre como agentes de encefalitis en el ser humano
(2014-07)Este artículo de revisión se enfoca en las amebas de vida libre, un tipo de protozoarios que habitan diferentes tipos de suelo y fuentes de agua. Estos organismos tienen dos estadios evolutivos: trofozoíto y quiste, siendo ... -
Primer aislamiento de Balamuthia mandrillaris en Costa Rica
(2014-07)En este estudio se determinó la presencia de Balamuthia mandrillaris en una muestra de polvo procedente de una unidad combinada de emergencia en Costa Rica. Se realizó un muestreo de polvo y agua en 12 unidades combinadas ... -
Diagnóstico de laboratorio de coccidios intestinales
(2013-01)Los coccidios intestinales son un grupo de parásitos unicelulares que infectan el tracto gastrointestinal de diferentes especies animales, incluyendo el ser humano. Los coccidios se transmiten por la ingestión de quistes ... -
Identificación de moléculas inmunorreguladoras inducidas por la bacteria Helicobacter pylori en modelos in vitro e in vivo
(2023)El cáncer gástrico (CG) es el cuarto tipo de cáncer más mortal a nivel mundial, principalmente por su detección tardía y la falta de terapias eficaces. La inmunoterapia ha mostrado ser muy prometedora en el tratamiento del ... -
Percentiles of body mass index and waist circumference for Costa Rican children and adolescents
(2022)Introduction: body mass index (BMI) and waist circumference (WC) are anthropometric indicators used to define overweight/obesity and to predict the risk of cardiovascular disease, respectively, in adolescents and ... -
Fatal meningoencephalitis in child and isolation of Naegleria fowleri from hot springs in Costa Rica
(2015-02)In summary, this investigation identified an N. fowleri ameba in water sources at a resort in Costa Rica that had been visited by a child from the United States who died of PAM as a results of N. fowleri infection. These ... -
Isolation and Molecular Characterization of Acanthamoeba Strains from Dental Units in Costa Rica
(2015-03)Free-living amoebae are protozoa widely distributed in nature, which can be found in a variety of environments. Four genera are recognized as causal agents of infections in humans and animals: Acanthamoeba, Naegleria, Balam ... -
Aplicación de la topología molecular en la predicción de la actividad antiprotozoaria de derivados del benzimidazol
(2013-03)Se ha aplicado la topología molecular a la búsqueda de nuevos derivados del benzimidazol con actividad antiprotozoaria frente a Trichomonas vaginalis y Giardia intestinalis. A partir de los resultados del análisis lineal ... -
Caso clínico: Rinoescleroma
(2013-01)The case of a 19–year–old male patient from a rural area is presented. He had a 3-year history of nasal obstruction, episodes of facial inflammation, epistaxis, fetid rhinorrhea, hearing loss in the right ear, bilateral ... -
Molecular Recognition of Surface Trans-Sialidases in Extracellular Vesicles of the Parasite Trypanosoma cruzi Using Atomic Force Microscopy (AFM)
(2022-06-28)Trans-sialidases (TS) are important constitutive macromolecules of the secretome present on the surface of Trypanosoma cruzi (T. cruzi) that play a central role as a virulence factor in Chagas disease. These enzymes have ... -
Biophysical and Biochemical Comparison of Extracellular Vesicles Produced by Infective and Non-Infective Stages of Trypanosoma cruzi
(2021-05-13)Extracellular vesicles (EVs) are small lipid vesicles released by either any prokaryotic or eukaryotic cell, or both, with a biological role in cell-to-cell communication. In this work, we characterize the proteomes and ... -
Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi
(2020-04-08)Background: Chagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side ... -
Primary Amebic Meningoencephalitis Related to Groundwater in Costa Rica: Diagnostic Confirmation of Three Cases and Environmental Investigation
(2020-08-01)During the first trimester of 2020, the Ministry of Health of Costa Rica reported the first three cases of primary amebic meningoencephalitis (PAM). In two cases, laboratory personnel of the hospitals preliminarily ... -
The Impact of Deforestation, Urbanization, and Changing Land Use Patterns on the Ecology of Mosquito and Tick-Borne Diseases in Central America
(2022)Central America is a unique geographical region that connects North and South America, enclosed by the Caribbean Sea to the East, and the Pacific Ocean to the West. This region, encompassing Belize, Costa Rica, Guatemala, ... -
Isolation of Acanthamoeba T5 from Water: Characterization of Its Pathogenic Potential, Including the Production of Extracellular Vesicles
(2020-01-23)Acanthamoeba is a genus of free-living amoebae widely distributed in nature, associated with the development of encephalitis and keratitis. Despite the fact that it is common to find genotype T5 in environmental samples, ... -
In vitro effects of environmental isolates of Acanthamoeba T4 and T5 over human erythrocytes and platelets
(2020-01-21)Free-living amoebae of the genus Acanthamoeba have been associated with keratitis and encephalitis. Some factors related to their pathogenic potential have been described, including the release of hydrolytic enzymes, and ...
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