Listar Medicina, ciencias biomédicas y salud pública por autor "6a5e0de9-4f0a-4988-b3a9-49373f6716f4"
Mostrando ítems 1-15 de 15
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Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica
Alpízar Alpízar, Warner; Pérez Pérez, Guillermo Ignacio; Une, Clas Allan; Cuenca Berger, Patricia; Sierra Ramos, Rafaela (Clinical and Experimental Medicine 5 p.169-176, 2005-09-13)Several risk factors have been associated with gastric cancer, among them Helicobacter pylori infection. This bacterium yields inflammation, the degree of which depends on the bacterial strain and the severity of the host ... -
Association of serum pepsinogen with atrophic body gastritis in Costa Rica
Sierra Ramos, Rafaela; Une, Clas Allan; Ramírez Mayorga, Vanessa; González Lutz, María Isabel; Ramírez, José A.; de Mascarel, Antoine; Barahona García, Ricardo; Salas Aguilar, Rigoberto; Páez, R.; Avendaño Alvarado, Gerardo; Ávalos Giugliarelli, Alessia; Broutet, N.; Mégraud, Francis (Clinical and Experimental Medicine 6 p.72-78, 2006-05-26)Abstract Individuals with atrophic gastritis (AG), especially atrophic body gastritis (ABG), are at increased risk of developing gastric cancer. Serum concentrations of pepsinogens (PG) have been proposed as markers for ... -
Helicobacter pylori infection and serum pepsinogen concentrations in an elderly population representative of Costa Rica
Une, Clas Allan; Malespín Bendaña, Wendy Karina; Ramírez Mayorga, Vanessa; Rosero Bixby, Luis; Sierra Ramos, Rafaela (2022)INTRODUCTION: Costa Rica has among the highest mortality rates from gastric cancer in the world, largely due to late detection. It is therefore important that economically and logistically sustainable screening is implemented ... -
Helicobacter pylori infection induces gastric precancerous lesions and persistent expression of Angpt2, Vegf-A and Tnf-A in a mouse model
Malespín Bendaña, Wendy Karina; Alpízar Alpízar, Warner; Figueroa Protti, Lucía; Reyes Moreno, Ledis; Molina Castro, Silvia Elena; Une, Clas Allan; Ramírez Mayorga, Vanessa (2023)Helicobacter pylori colonizes the gastric mucosa and induces chronic inflammation. Using a mouse model of H. pylori-induced gastritis, we evaluated the mRNA and protein expression levels of proinflammatory and proangiogenic ... -
Helicobacter pylori infection induces abnormal expression of pro‑angiogenic gene ANGPT2 and miR‑203a in AGS gastric cell line
Malespín Bendaña, Wendy Karina; Ferreira, Rui M.; Pinto, Marta T.; Figueiredo, Ceu; Alpízar Alpízar, Warner; Une, Clas Allan; Figueroa Protti, Lucía; Ramírez Mayorga, Vanessa (2023-03-06)Helicobacter pylori colonizes the stomach and induces an inflammatory response that can develop into gastric pathologies including cancer. The infection can alter the gastric vasculature by the deregulation of angiogenic ... -
La inflamacion y su papel en el desarrollo del cáncer gástrico
Alpízar Alpízar, Warner; Une, Clas Allan; Sierra Ramos, Rafaela (Acta Medica Cnstarricense Vol 51 (2):76-82, abril-junio 2009, 2009-04)La infección por Helicobacter pylori produce, en algunos pacientes, inflamación crónica en el estómago, gastritis atrófica y cáncer gástrico. Los mecanismos moleculares que conducen de la infección a la inflamación crónica ... -
Pepsinógenos séricos para detectar cáncer gástrico en Costa Rica
Sierra Ramos, Rafaela; Mena, Fernando; Ramírez Mayorga, Vanessa; Méndez Chacón, Ericka; Salazar, Maritza; Une, Clas Allan; Kajiwara, Tetsuro (Ada Bioquirnice Minion Latinoamericana ; 37 (4): 357-62, 2003)Las concentraciones de pepsinagenos (PG) I y II en suero, reflejan el estado funcional y morfológico de la mucosa gástrica. En este estudio se determinaron los puntos de corte óptimos de los niveles séricos de PGI, PGII y ... -
Polymorphisms in Genes Coding for HSP-70 Are Associated with Gastric Cancer and Duodenal Ulcer in a Population at High Risk of Gastric Cancer in Costa Rica
Ferrera Ferrera, Maura; Malespín Bendaña, Wendy Karina; Ramírez Mayorga, Vanessa; González Lutz, María Isabel; Carvajal, Adriana; Une, Clas Allan (2013)Background and Aims. Costa Rica has among the highest incidence and mortality rates for gastric cancer worldwide. The reasons for this are largely unknown. Polymorphisms of inflammatory response genes including genes ... -
Role of nitric oxide in the immunosuppressive effect of trypanosoma lewisi on multiplication of toxoplasma gondii in white rats
Ríos Carrera, Nivia Judith; Guerrero Bermúdez, Olga Marta; Chinchilla Carmona, Misael; Une, Clas Allan (2013)The role of nitric oxide in the immunosuppressive effect of Trypanosoma lewisi on the response to Toxoplasma gondii in WISTAR rats was evaluated. Two groups of rats were infected with T. gondii tachyzoites. One of these ... -
Seroprevalence of Helicobacter pylori/CagA Antibodies in Guatemalan Gastric Cancer Patients: Association of Seropositivity with Increased Plasma Levels of Pepsinogens but not Soluble Urokinase Plasminogen Activator Receptor
Fernández Botrán, Rafael; Wellmann, Irmgardt Alicia; Une, Clas Allan; Méndez Chacón, Ericka; Hernández de Rodas, Elisa; Bhandari, Bikash; Villagrán, Carmen I. (2020)Infection by Helicobacter pylori is a major risk factor for gastric cancer (GC), the second leading cause of cancer-related death worldwide. Although biomarkers such as pepsinogens (PGs) and soluble urokinase plasminogen ... -
The geographic origin of Helicobacter pylori isolated from Costa Rican patients
Molina Castro, Silvia Elena; Herrera Ríos, Dayana; Malespín Bendaña, Wendy Karina; Ramírez Mayorga, Vanessa; Une, Clas Allan (2014-07)Helicobacter pylori infects a significant proportion of the world population and it is associated with pathologies which include chronic atrophic gastritis, peptic ulcer, and gastric neoplasias such as gastric adenocarcinoma ... -
The TNF-A–857*T polymorphism is associated with gastric adenocarcinoma risk in a Costa Rican population
Malespín Bendaña, Wendy Karina; Machado, José Carlos; Une, Clas Allan; Alpízar Alpízar, Warner; Molina Castro, Silvia Elena; Ramírez Mayorga, Vanessa (2021-01)Background: Costa Rica is ranked as one of the countries with highest incidence of gastric cancer worldwide. Previous studies in Costa Rican populations have revealed associations between gastric cancer risk and several ... -
Validación de una prueba serológica para detectar la infección por Helicobacter pylori en Costa Rica
Méndez Chacón, Ericka; Ramírez Mayorga, Vanessa; Malespín Bendaña, Wendy Karina; Pérez Pérez, Guillermo Ignacio; Une, Clas Allan (2020)Helicobacter pylori es una bacteria Gram negativa capaz de sobrevivir y multiplicarse en la mucosa gástrica humana. Es el factor más importante en el desarrollo de gastritis atrófica crónica, ... -
Valor diagnóstico de las proteínas uPAR en sangre para el cáncer gástrico en Guatemala
Wellmann, Irmgardt Alicia; Villagrán, Carmen I.; Fernández Botrán, Rafael; Hernández, Elisa; Méndez Chacón, Ericka; Une, Clas Allan (2018)El cáncer gástrico es la neoplasia más frecuente del tubo digestivo, Guatemala posee altas tasas de incidencia y mortalidad. Helicobacter pylori se ha identificado como un carcinógeno gástrico, especialmente si la infección ... -
Virulence factor genotyping of Helicobacter pylori isolated from Costa Rican dyspeptic patients
Molina Castro, Silvia Elena; Garita Cambronero, Jerson; Malespín Bendaña, Wendy Karina; Une, Clas Allan; Ramírez Mayorga, Vanessa (2019-01-14)Background and aims: Costa Rica is one of the countries with the highest incidence and mortality rates for gastric cancer. Helicobacter pylori infection rates are high in the whole country. We have previously shown that ...