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Mitochondrial polymorphisms are associated both with increased and decreased longevity
(Hum Hered 2009;67:147–153, 2008-12-15)
Previous work compared frequency of longevity-associated polymorphisms (LAPS) in long-lived individuals and in controls from the general population (primarily in Europe and Japan), suggesting the polymorphisms are responsible ...
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation
(J Mol Med (Berl). 2010 November ; 88(11): 1133–1141, 2010-11)
Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune ...
A schizophrenia gene locus on chromosome 17q21 in a new set of families of mexican and central american ancestry: evidence from the NIMH genetics of schizophrenia in latino populations study
(Am J Psychiatry 2009;166:442-449, 2009-02-02)
The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders. Method: A genome-wide scan was performed ...
Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in latinos: a family-based association study
(Bipolar Disorders 2013: 15: 206–214, 2013-02-25)
Objectives: Through recent genome-wide association studies (GWASs),
several groups have reported significant association between variants in
the calcium channel, voltage-dependent, L-type, alpha 1C subunit
(CACNA1C) and ...
Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder
(Journal of Affective Disorders xxx (2011) xxx–xxx, 2011)
Bipolar disorder (BPD) has been associated with variations in personality dimensions,
but the nature of this relationship has been unclear. Inthis study, theheritabilities of BPDandtheBig
Five personality factors and the ...
The gene for an inherited form of deafness maps to chromosome 5q31
(1992-06-01)
Primary-i.e., nonsyndromal-postlingual deafness is inherited as an autosomal dominant phenotype in a large kindred in Costa Rica. Genetically susceptible individuals begin to lose hearing at low frequencies at about age ...
Caracterización clínica de familias costarricenses con trastorno afectivo bipolar
Clinical characterization of costarican families with bipolar disorder
(2014-12)
Justificación y objetivos: la heterogeneidad clínica del trastorno afectivo bipolar tipo I constituye
uno de los principales desafíos en el diagnóstico de dicha enfermedad. Se necesitan múltiples
fuentes de información ...
Heritability of Age of Onset of Psychosis in Schizophrenia
(AMERICAN JOURNAL OF MEDICAL GENETICS PART B, 2009-04)
Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age ofonset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due ...
Association of Apolipoprotein E-e4 and Dementia Declines with Age
(2014-10)
To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample).
In both case-control ...
High mitochondrial mutation rates estimated from deep-rooting Costa Rican pedigrees
(American Journal of Physical Anthropology 2012 July ; 148(3): 327–333., 2012-07)
Estimates of mutation rates for the noncoding hypervariable Region I (HVR-I) of mitochondrial
DNA (mtDNA) vary widely, depending on whether they are inferred from phylogenies (assuming
that molecular evolution is clock-like) ...