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Differences in the association of cardiovascular risk factors with education: a comparison of Costa Rica (CRELES) and the USA (NHANES)
(J Epidemiol Community Health 2010; 64: 821-828, 2009-08-12)
Background Despite different levels of economic
development, Costa Rica and the USA have similar
mortalities among adults. However, in the USA there are
substantial differences in mortality by educational
attainment, ...
Seasonal Variation of Peripheral Blood Leukocyte Telomere Length in Costa Rica: A Population-Based Observational Study
(2014)
ABSTRACT: Objectives: Peripheral blood leukocyte telomere length (LTL) is increasingly being used as a biomarker of aging, but its natural variation in human populations is not well understood. Several other biomarkers ...
A cross-national comparison of 12 biomarkers finds no universal biomarkers of aging among individuals aged 60 and older
(2016)
There is uncertainty about whether biological and anthropometric measures that are
clinical risk factors for disease are universally associated with chronological age,
or whether these correlations vary depending on the ...
Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based study
(2013)
Studies in humans suggest that leukocyte telomere length may act as a marker of biological aging. We investigated whether individuals in the Nicoya region of Costa Rica, known for exceptional longevity, had longer telomere ...
Predicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Study
(2016-04)
Telomere length has generated substantial interest as a potential predictor of aging- related diseases and mortality. Some studies have reported significant associations, but few have tested its ability to discriminate ...
Epigenome-Wide Association Study and Epigenetic Age Acceleration Associated with Cigarette Smoking among Costa Rican Adults
(2022-03-11)
Smoking-associated DNA methylation (DNAm) signatures are reproducible among studies of mostly European descent, with mixed evidence if smoking accelerates epigenetic aging and its relationship to longevity. We evaluated ...
The Nicoya region of Costa Rica: A high longevity island for elderly males
(Vienna Yearbook of Population Research, Vol 11, 2013-11)
Reliable data show that the Nicoyan region of Costa Rica is a hot spot of high
longevity. A survival follow-up of 16,300 elderly Costa Ricans estimated a Nicoya
death rate ratio (DRR) for males 1990–2011 of 0.80 (0.69–0.93 ...
Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region
(2017)
Background: The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is ...