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The gene for an inherited form of deafness maps to chromosome 5q31
(1992-06-01)
Primary-i.e., nonsyndromal-postlingual deafness is inherited as an autosomal dominant phenotype in a large kindred in Costa Rica. Genetically susceptible individuals begin to lose hearing at low frequencies at about age ...
Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion
(Nucleic Acids Research 42(11) p. 7047–7056, 2014-05-01)
Genetically unstable expanded CAG·CTG trinucleotide repeats are causal in a number of human disorders, including Huntington disease and myotonic dystrophy type 1. It is still widely assumed that DNA polymerase slippage ...
Individual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotropin-releasing factor receptor 1 in the nucleus accumbens
(Behavioural Brain Research, Vol. 252. pp. 77-87, 2013)
The study of individual differences provides an important methodological approach to analyze the
neurobehavioral spectrum of a given cohort in order to understand brain function and disease. Based
on immobility time in ...
A schizophrenia gene locus on chromosome 17q21 in a new set of families of mexican and central american ancestry: evidence from the NIMH genetics of schizophrenia in latino populations study
(Am J Psychiatry 2009;166:442-449, 2009-02-02)
The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders. Method: A genome-wide scan was performed ...
Predicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Study
(2016-04)
Telomere length has generated substantial interest as a potential predictor of aging- related diseases and mortality. Some studies have reported significant associations, but few have tested its ability to discriminate ...
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation
(J Mol Med (Berl). 2010 November ; 88(11): 1133–1141, 2010-11)
Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune ...
TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties
(2020)
Helicobacter pylori infection, the main risk factor for gastric cancer (GC), leads to an epithelial–mesenchymal transition (EMT) of gastric epithelium contributing to gastric cancer stem cell (CSC) emergence. The Hippo ...
Stressors Over the Life Course and Neuroendocrine System Dysregulation in Costa Rica
(Journal of Aging and Health XX(X) 1–24, 2010-05-28)
Objectives: A key aspect of the increasingly popular allostatic load (AL) framework is that stressors experienced over the entire life course result in physiological dysregulation. Although core to AL theory, this idea has ...
Linfoma Hodgkin clásico rico en linfocitos, linfoma Hodgkin nodular de predominio linfocítico y linfoma de células B grandes rico en células T e histiocitos: comparación entre tres entidades relacionadas
(2021)
El linfoma Hodgkin nodular de predominio linfocítico (NLPHL por sus siglas en inglés) es una neoplasia de células B centrogerminales indolente que afecta adultos jóvenes. Está íntimamente relacionado con el linfoma de ...
Realización de estudios radiológicos para la disminución en las listas de espera del Servicio de Radiología e Imágenes Medicas de la Clínica Dr. Ricardo Jimenez Nuñez- Área de Salud Goicoechea 2 julio 2021
(2021)
Resumen
El Cáncer de mama continúa siendo en Costa Rica y en el mundo una de las patologías que con la frecuencia se presentan en la mujer con alta tasa en causa de mortalidad; ocupando en nuestro país la segunda causa ...