Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

Floriano, Rafael Stuani; Barilli Nogueira, Rosa Maria; Sakate, Michiko; Braga Lapozy, Cecília; Pereira da Motta, Yudney; Sangiorgio, Fabíola; Costa David, Heloísa; Nabas, João Marcelo

dc.creator	Floriano, Rafael Stuani
dc.creator	Barilli Nogueira, Rosa Maria
dc.creator	Sakate, Michiko
dc.creator	Braga Lapozy, Cecília
dc.creator	Pereira da Motta, Yudney
dc.creator	Sangiorgio, Fabíola
dc.creator	Costa David, Heloísa
dc.creator	Nabas, João Marcelo
dc.date	2009-11-20
dc.date.accessioned	2016-05-03T15:27:53Z
dc.date.available	2016-05-03T15:27:53Z
dc.identifier	http://revistas.ucr.ac.cr/index.php/rbt/article/view/5437
dc.identifier	10.15517/rbt.v57i4.5437
dc.identifier.uri	https://hdl.handle.net/10669/26246
dc.description	Crotalic envenomation represents the highest number of deaths when compared to other snakebite envenomations of medical interest. Crotalic venom has important characteristics such as neurotoxicity, myotoxicity, nephrotoxicity, and clotting and hemolytic action. We evaluated the clinical and laboratory aspects of Crotalus durissus terrificus experimental envenomation in Wistar rats treated with antivenom and the aqueous extract of the plant Mikania glomerata. The animals were divided into three groups: Group C (control); Group VS-venom and antivenom; Group VSM-venom, antivenom and aqueous extract of M. glomerata. Crotalic poison caused clinical and laboratory alterations in Wistar mice. Significant clinical alterations were: temperature decrease, edema in the venom inoculated member, sedation and a locomotion decrease in groups VS and VSM when compared with group C. A faster recovery from sedation was observed only for animals of group VSM when compared to VS. There was an increase in the number of leukocytes, neutrophils and creatine kinase in the VS and VSM groups, compared to group C. Wistar rats showed a high resistance to crotalic venom. Additional studies with different doses, time of treatment, different administration methods and histopathological and immunological studies are necessary to understand the action of M. glomerata in crotalic accidents.	en-US
dc.format	application/pdf
dc.language	eng
dc.publisher	Universidad de Costa Rica	en-US
dc.rights	Copyright (c) 2014 International Journal of Tropical Biology and Conservation	en-US
dc.source	Revista de Biología Tropical/International Journal of Tropical Biology and Conservation; Vol. 57 (4) December 2009	en-US
dc.source	Revista de Biología Tropical/International Journal of Tropical Biology and Conservation; Vol. 57 (4) December 2009	es-ES
dc.source	Revista Biología Tropical; Vol. 57 (4) December 2009	pt-PT
dc.source	2215-2075
dc.source	0034-7744
dc.source	10.15517/rbt.v57i4
dc.title	Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats	en-US
dc.title	Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats	es-ES
dc.type	artículo original
dc.coverage	CRC	en-US

Ficheros en el ítem

Ficheros	Tamaño	Formato	Ver
No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Revista de Biología Tropical [2107]

Mostrar el registro sencillo del ítem