Listar Biología por procedencia "UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química"
Mostrando ítems 1-20 de 30
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A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity
(2012)Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria, there is a pressing need for novel antibacterial agents. Here we report the development of a sensitive and robust but low-tech and ... -
Aceites esenciales, fenología e interacciones bióticas de la planta invasora Crassocephalum crepidioides (Asteraceae) en Costa Rica
(2022-12)Crassocephalum crepidioides (Asteraceae) es una especie herbácea con notables usos etnobotánicos en África y otras áreas, que se extendió como invasora en varias regiones tropicales y subtropicales del mundo. Objetivo: ... -
Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis
(2015)Oral squamous cell carcinoma (OSCC) is the most common cancer affecting the oral cavity, and US clinics will register about 30,000 new patients in 2015. Current treatment modalities include chemotherapy, surgery, and ... -
Brachiopods, sipunculans, enteropneusts and metals from two estuarine tidal flats, Pacific, Costa Rica
(2016-09)Reports on the abundances and on metal concentrations in intertidal estuarine invertebrates from the Eastern Tropical Pacific are rare. Thus, the objectives of this report are to make accessible data on the abundances ... -
C1 compounds shape the microbial community of an abandoned century-old oil exploration well
(2020)The search for microorganisms that degrade hydrocarbons is highly relevant because it enables the bioremediation of these substances cheaply and without dangerous by-products. In this work, we studied the microbial communities ... -
Composition of the essential oil from leaves of Smallanthus quichensis (Asteraceae) from Costa Rica
(2015-09-30)Smallanthus is a genus of flowering plants in the Asteraceae family, which has about 24 species, ranging mostly from southern Mexico and Central America to the Andes in South America. The aim of the present study was to ... -
Current approaches to the isolation and structural elucidation of active compounds from natural products
(2018)The essence of medicinal plants, either as pure compounds or as standardized extracts, provides unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. Due to an increasing ... -
Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments
(2017)High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal ... -
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
(2015-05-20)Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ... -
Essential oil composition of Ambrosia cumanensis (Asteraceae) from Costa Rica
(2015-08)Ambrosia is an Asteraceous genus of flowering plants, which has about 40-45 species, and their geographical distribution ranges from the USA, Mexico, and Central America to South America. The aim of this work was to study ... -
Genetic analysis of the dry forest timber tree Sideroxylon capiri in Costa Rica using AFLP
(2015-01)Sideroxylon capiri (“Tempisque”) is a threatened and economically important timber species in the dry forest of Costa Rica. To assess the extent of the genetic diversity between and within populations of this species, 86 ... -
Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp.
(2012)CR1642D, an endophytic isolate of Penicillium sp. collected from a Costa Rican rainforest, was identified through a high-throughput approach to identify natural products with enhanced antitumor activity in the context of ... -
Interplay of the PtsN (EIIANtr) protein of Pseudomonas putida with its target sensor kinase KdpD
(2015-08-27)The nitrogen phosphotransferase system (PTSNtr) of Pseudomonas putida is a multi-component regulatory device that participates in controlling a variety of physiological processes in a post-translational fashion. A general ... -
Leaf and flower essential oil compositions of Gliricidia sepium (Fabaceae) from Costa Rica
(2015-04)Gliricidia is a small genus of flowering plants in the Fabaceae family. Gliricidia sepium is a multipurpose tree native to Mesoamerica and possibly northern South America. The chemical composition of the hydrodistilled ... -
Mastering analytical challenges for the characterization of pentacyclic triterpene mono- and diesters of Calendula officinalis flowers by non-aqueous C30 HPLC and hyphenation with APCI-QTOF-MS
(2016-01-25)Pentacyclic triterpene mono- and diesters have been isolated from Calendula officinalis flowers. GC–MS, APCI-Exactive Orbitrap HR-MS and NMR allowed to identify the triterpene skeleton in various samples (different triterpene ... -
Maternal health in Central America: The role of medicinal plants in the pregnancy-related health and well-being of indigenous women in Central America
(2018)Over the past 20 years, Central America (CA) has made considerable progress in improving the health status of its populations. However, in some countries, the overall health status remains below average with poor outcomes ... -
Molecular data indicate that Rhytidhysteron rufulum (ascomycetes, Patellariales) in Costa Rica consists of four distinct lineages corroborated by morphological and chemical characters
(2009)Rhytidhysteron rufulum is a poorly known, common, pantropical species, capable of utilizing different substrata and occupying diverse habitats, and is the only species of its genus in Costa Rica. We have employed molecular, ... -
Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts
(2015-07-06)As part of the International Cooperative Biodiversity Groups (ICBG) Program, we were interested in identifying biologically active unfolded protein response (UPR) inducing compounds from marine microorganisms isolated from ... -
Production of selenium nanoparticles in Pseudomonas putida KT2440
(2016)Selenium (Se) is an essential element for the cell that has multiple applications in medicine and technology; microorganisms play an important role in Se transformations in the environment. Here we report the previously ... -
Quantitative Physiology Approaches to Understand and Optimize Reducing Power Availability in Environmental Bacteria
(2015-06-04)The understanding of how carbon fluxes are distributed through a metabolic network offers an overview of the pathways that a given microorganism uses to produce energy, reducing power, and biomass. These invaluable data ...