ListarQuímica por tema "Natural products"
Mostrando ítems 1-3 de 3
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Adipostatins E-J, new potent antimicrobials identified as inhibitors of coenzyme-A biosynthesis
(2020-01)Phosphopantetheine is a key structural element in biological acyl transfer reactions found embedded within coenzyme A (CoA). Phosphopantothenoylcysteine synthetase (PPCS) is responsible for installing a cysteamine group ... -
Crystal structures and biological activity of 1,1,4-triphenyl-substituted 1,3-enyne compounds
(2019)1,3-Enyne structural motifs are versatile building blocks in organic synthesis and occur widely in various natural products with many of them being highly active as cytotoxic macrolides and antitumour antibiotics. This ... -
Natural product based inhibitors of the thioredoxin-thioredoxin reductase system
(2004)Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone ...