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Seco-manool and other constituents from fleischmannia microstemon
(1988-01)
The aerial parts of Fleischmannia microstemon afforded in addition to sesamin and two clerodanes, ent-manoyl oxide and two derivatives of the latter, one a 6β-acetoxy derivative and the other a seco-labdane. From F. pratensis ...
Identification of polyphenols from antiviral Chamaecrista nictitans extract using high-resolution LC–ESI–MS/MS
(2014)
Chamaecrista nictitans (L) extract possesses antiviral properties; it acts against the herpes simplex virus, and this may be attributed to its constituent phenolics. Here, high-resolution LC–ESI–MS/MS is used to identify ...
Separation of crude plant extracts with high speed CCC for primary screening in drug discovery
(2001)
High speed countercurrent chromatography (HSCCC) was used
in a pre-fractionation pilot study to improve the quality of crude
plant samples for primary screening in drug discovery efforts. The
methanol ...
Clibadiolide, a sesquiterpene lactone esterified with a homoditerpene from Clibadium pittierii
(1988)
The aerial parts of Clibadium pittierii afforded in addition to known melampolides two new ones, one being esterified with a homoditerpenic acid and the homoditerpenic acid itself. The structures were elucidated by high ...
Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
(2013)
From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known ...
Phenolic compounds as antiangiogenic CMG2 inhibitors from costa rican endophytic fungi
(2012)
Targeting and inhibiting CMG2 (Capillary Morphogenesis Gene protein 2) represents a new strategy for therapeutic agents for cancer and retinal diseases due to CMG2’s role in blood vessel growth (angiogenesis). A high ...
Bioprospecting
(2001)
Bioprospecting is the systematic search for genes, natural compounds designs and whole organisms in wild life with a potential for product development by biological observation and biophsical, biochemical, and genetic ...
Identification of Protein Kinase C Activation as a Novel Mechanism for RGS2 Protein Upregulation through Phenotypic Screening of Natural Product Extracts
(2014)
Biochemical high-throughput screening is widely used in drug discovery, using a variety of small molecule libraries. However, broader screening strategies may be more beneficial to identify novel biologic mechanisms. In ...
Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis
(2014)
Siderophores are high-affinity iron chelators produced by microorganisms and frequently contribute to the virulence of human pathogens. Targeted inhibition of the biosynthesis of siderophores staphyloferrin B of Staphylococcus ...
Uncovering the Cultivable Microbial Diversity of Costa Rican Beetles and Its Ability to Break Down Plant Cell Wall Components
(2014)
Coleopterans are the most diverse insect order described to date. These organisms have acquired an array of survival mechanisms through their evolution, including highly efficient digestive systems. Therefore, the coleopteran ...