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dc.creatorGarcía Barrantes, Pedro M.es_ES
dc.creatorLamoureux Lamontagne, Guyes_ES
dc.creatorPérez Sánchez, Alice Lorenaes_ES
dc.creatorGarcía Sánchez, Rory N.es_ES
dc.creatorMartínez, Antonio R.es_ES
dc.creatorSan Feliciano, Arturoes_ES
dc.date.accessioned2016-07-28T22:31:53Zes_ES
dc.date.available2016-07-28T22:31:53Zes_ES
dc.date.issued2013-12es_ES
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0223523413006521es_ES
dc.identifier.issn0223-5234es_ES
dc.identifier.urihttps://hdl.handle.net/10669/28845es_ES
dc.description.abstractThis work deals with the synthesis and evaluation of new compounds designed by combination of 1,4-naphthoquinone and ferrocene fragments in a 3-ferrocenylmethyl-2-hydroxy-1,4-naphthoquinone arrangement. A practical coupling reaction between 2-hydroxy-1,4-naphthoquinone and ferrocenemethanol derivatives has been developed. This procedure can be carried out “on-water”, at moderate temperatures and without auxiliaries or catalysts, with moderate to high yields. The synthesized derivatives have shown significant in vitro antiplasmodial activity against chloroquine-sensitive and resistant Plasmodium falciparum strains and it has been shown that this activity is not related to the inhibition of biomineralization of ferriprotoporphyrin IX. Binding energy calculations and docking of these compounds to cytochrome b in comparison with atovaquone have been performed.es_ES
dc.description.sponsorshipSpanish FIS-ISCIII Program (project No. PI060782)es_ES
dc.description.sponsorshipUniversidad de Costa Ricaes_ES
dc.description.sponsorshipConsejo Nacional de Rectoreses_ES
dc.language.isoen_USes_ES
dc.sourceEuropean Journal of Medicinal Chemistry 70:548-557. 2013es_ES
dc.subjectNaphthoquinonees_ES
dc.subjectLawsonees_ES
dc.subjectFerrocenees_ES
dc.subjectAntimalariales_ES
dc.subjectOn-water reactionses_ES
dc.titleSynthesis and biological evaluation of novel ferrocene–naphthoquinones as antiplasmodial agentses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.ejmech.2013.10.011es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)es_ES
dc.identifier.codproyecto809-A8-001es_ES
dc.identifier.codproyecto809-A8- 518es_ES


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