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Proteoform-resolved quantitative venomics: looking through a crystal ball
dc.creator | Calvete Chornet, Juan José | |
dc.creator | Petras, Daniel | |
dc.creator | Calderón Celis, Francisco | |
dc.creator | Lomonte, Bruno | |
dc.creator | Ruiz Encinar, Jorge | |
dc.creator | Sanz Medel, Alfredo | |
dc.date.accessioned | 2018-06-01T15:04:08Z | |
dc.date.available | 2018-06-01T15:04:08Z | |
dc.date.issued | 2017-04 | |
dc.identifier.citation | https://jvat.biomedcentral.com/articles/10.1186/s40409-017-0116-9 | |
dc.identifier.issn | 1678-9199 | |
dc.identifier.uri | https://hdl.handle.net/10669/74787 | |
dc.description.abstract | In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflects | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad/[BFU2013-42833-P]//España | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad/[BES-2014-068032]//España | es_ES |
dc.language.iso | en_US | es_ES |
dc.rights | CC0 1.0 Universal | * |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.source | Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 23(27) | es_ES |
dc.subject | Top-down proteomics | es_ES |
dc.subject | Top-down venomics | es_ES |
dc.subject | Protein species resolved venomic | es_ES |
dc.subject | Absolute quantification | es_ES |
dc.subject | Inductively coupled plasma mass spectrometry | es_ES |
dc.subject | Snake venom | es_ES |
dc.title | Proteoform-resolved quantitative venomics: looking through a crystal ball | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1186/s40409-017-0116-9 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
dc.identifier.pmid | 28465678 | |
dc.identifier.pmid | PMC5408492 |
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