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Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region
dc.creator | McEwen, Lisa M. | |
dc.creator | Morin, Alexander M. | |
dc.creator | Edgar, Rachel D. | |
dc.creator | MacIsaac, Julia L. | |
dc.creator | Jones, Meaghan J. | |
dc.creator | Dow, William H. | |
dc.creator | Rosero Bixby, Luis | |
dc.creator | Kobor, Michael S. | |
dc.creator | Rehkopf, David H. | |
dc.date.accessioned | 2018-07-27T20:22:45Z | |
dc.date.available | 2018-07-27T20:22:45Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-017-0128-2 | |
dc.identifier.issn | 1756-8935 | |
dc.identifier.uri | https://hdl.handle.net/10669/75304 | |
dc.description.abstract | Background: The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population’s unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts. Methods: In a cross-sectional subsample of the Costa Rican Longevity and Healthy Aging Study, we compared whole blood DNA methylation profiles of residents from Nicoya (n = 48) and non-Nicoya (other Costa Rican regions, n = 47) using the Infinium HumanMethylation450 microarray. Results: We observed a number of differences that may be markers of delayed aging, such as bioinformatically derived differential CD8+ T cell proportions. Additionally, both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans. We also observed lower overall variability in DNA methylation in the Nicoyan population, another hallmark of younger biological age. Conclusions: Nicoyans represent an interesting group of individuals who may possess unique immune cell proportions as well as distinct differences in their epigenome, at the level of DNA methylation. | es_ES |
dc.description.sponsorship | Center on the Economics and Demography of Aging/[P30AG012839]/CEDA/Estados Unidos | es_ES |
dc.description.sponsorship | Canadian Institute of Health Research/[F16-00910]/CIHR/Canadá | es_ES |
dc.description.sponsorship | R. Howard Webster Foundation/[F13-00031]//Canadá | es_ES |
dc.description.sponsorship | National Institute of Aging/[K01 AG047280]/NIA/Estados Unidos | es_ES |
dc.description.sponsorship | Wellcome Trust Grant/[072406]//Reino Unido | es_ES |
dc.description.sponsorship | Canadian Institute of Health Research/[F15‑04283]/CIHR/Canadá | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Epigenetics & Chromatin,vol.10(21),pp.1-14 | es_ES |
dc.subject | Metilación de ADN | es_ES |
dc.subject | Epigenetica | es_ES |
dc.subject | Envejecimiento inmune | es_ES |
dc.subject | Longevidad | es_ES |
dc.subject | Biodemografía | es_ES |
dc.subject | 571.879 728 6 Longevidad | es_ES |
dc.subject | DNA methylation | es_ES |
dc.subject | Epigenetics | es_ES |
dc.subject | Immune aging | es_ES |
dc.subject | Longevity | es_ES |
dc.subject | Biodemography | es_ES |
dc.subject | Epigenetic age | es_ES |
dc.title | Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1186/s13072-017-0128-2 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP) | es_ES |